Detailed information of TA system TA078155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2357793..2358488
• Replicon: chromosome
• Accession: NZ_CP022014
• Organism: Mycobacterium tuberculosis strain MTB2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: O53501
• Locus tag: B7R63_RS11370
• Protein ID: WP_003410811.1
• Coordinates: 2357793..2358227 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B7R63_RS11375
• Protein ID: WP_003902124.1
• Coordinates: 2358234..2358488 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7R63_RS11360	2353947..2356988	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
B7R63_RS11365	2356981..2357814	+	834	WP_003899172.1	SWIM zinc finger family protein	-
B7R63_RS11370	2357793..2358227	-	435	WP_003410811.1	type II toxin-antitoxin system VapC family toxin	Toxin
B7R63_RS11375	2358234..2358488	-	255	WP_003902124.1	antitoxin	Antitoxin
B7R63_RS11380	2358504..2358761	-	258	WP_003410816.1	hypothetical protein	-
B7R63_RS11390	2359708..2360004	+	297	WP_003410820.1	PE family protein	-
B7R63_RS11395	2360060..2360791	+	732	WP_003900467.1	PPE family protein	-
B7R63_RS11400	2361331..2362077	-	747	WP_003901330.1	proteasome subunit alpha	-
B7R63_RS11405	2362074..2362949	-	876	WP_003411023.1	proteasome subunit beta	-
B7R63_RS11410	2362946..2363140	-	195	WP_003411026.1	ubiquitin-like protein Pup	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15662.08 Da
• Isoelectric Point: 7.4681

>T78155 WP_003410811.1 NZ_CP022014:c2358227-2357793 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T78155 NZ_CP022014:c2358227-2357793 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9403.54 Da
• Isoelectric Point: 8.9912

>AT78155 WP_003902124.1 NZ_CP022014:c2358488-2358234 [Mycobacterium tuberculosis]
MRTTVSLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT78155 NZ_CP022014:c2358488-2358234 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCTCATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Toxin

• AlphaFold DB: A0A7U4FB09