Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2184051..2184595 Replicon chromosome
Accession NZ_CP022014
Organism Mycobacterium tuberculosis strain MTB2

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag B7R63_RS10500 Protein ID WP_003409896.1
Coordinates 2184051..2184347 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag B7R63_RS10505 Protein ID WP_003409899.1
Coordinates 2184344..2184595 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R63_RS10445 2179084..2179434 - 351 WP_003409871.1 hypothetical protein -
B7R63_RS10450 2179445..2180347 - 903 WP_003899097.1 hypothetical protein -
B7R63_RS10455 2180368..2180559 - 192 WP_003409876.1 hypothetical protein -
B7R63_RS10460 2180560..2180856 - 297 WP_003409877.1 hypothetical protein -
B7R63_RS10465 2181096..2181311 + 216 WP_003409878.1 antitoxin -
B7R63_RS10470 2181308..2181619 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
B7R63_RS21845 2181593..2182114 - 522 WP_003904745.1 hypothetical protein -
B7R63_RS10480 2182089..2182466 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
B7R63_RS10485 2182508..2182957 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
B7R63_RS10490 2182954..2183499 + 546 WP_003409891.1 SecB-like chaperone -
B7R63_RS10495 2183388..2184002 - 615 WP_003901296.1 hypothetical protein -
B7R63_RS10500 2184051..2184347 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7R63_RS10505 2184344..2184595 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
B7R63_RS10510 2184582..2185076 + 495 WP_003899099.1 hypothetical protein -
B7R63_RS10515 2185236..2185643 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
B7R63_RS10520 2185647..2185919 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
B7R63_RS10525 2185952..2187172 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
B7R63_RS10540 2188071..2188868 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T78148 WP_003409896.1 NZ_CP022014:c2184347-2184051 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T78148 NZ_CP022014:c2184347-2184051 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT78148 WP_003409899.1 NZ_CP022014:c2184595-2184344 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT78148 NZ_CP022014:c2184595-2184344 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References