Detailed information of TA system TA078113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 983025..983607
• Replicon: chromosome
• Accession: NZ_CP022013
• Organism: Mergibacter septicus strain 27517-4-I1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEP47_RS04640
• Protein ID: WP_261920732.1
• Coordinates: 983308..983607 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEP47_RS04635
• Protein ID: WP_261920733.1
• Coordinates: 983025..983318 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP47_RS04620 (CEP47_04575)	978914..980221	-	1308	WP_261920736.1	histidinol dehydrogenase	-
CEP47_RS04625 (CEP47_04580)	980230..981129	-	900	WP_261920735.1	ATP phosphoribosyltransferase	-
CEP47_RS04630 (CEP47_04585)	981578..982828	+	1251	WP_261920734.1	tryptophan permease	-
CEP47_RS04635 (CEP47_04590)	983025..983318	+	294	WP_261920733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CEP47_RS04640 (CEP47_04595)	983308..983607	+	300	WP_261920732.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CEP47_RS04645 (CEP47_04600)	983825..984118	+	294	WP_261920731.1	DUF1778 domain-containing protein	-
CEP47_RS04650 (CEP47_04605)	984115..984633	+	519	WP_261920730.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (13-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-86)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11566.36 Da
• Isoelectric Point: 8.0629

>T78113 WP_261920732.1 NZ_CP022013:983308-983607 [Mergibacter septicus]
MKNESNKVQNYVLSKRFKKDITNLSKSHPEILISKRFTEVFNLLINGKPLPEIYKDHALSGNMQGIRDCHIYNDLILLYE
IKEDVISFIRLGSHSELFD

Nucleotide

• Length: 300 bp

>T78113 NZ_CP022013:983308-983607 [Mergibacter septicus]
ATGAAGAATGAATCGAATAAAGTTCAGAATTATGTATTATCCAAACGTTTTAAAAAAGATATTACCAATTTATCAAAATC
TCACCCTGAAATTTTAATTAGTAAACGTTTTACGGAAGTTTTTAATCTATTGATAAACGGAAAGCCTCTTCCTGAAATTT
ATAAAGATCACGCTTTATCGGGAAATATGCAAGGGATACGAGATTGCCATATCTATAACGATCTCATATTACTTTACGAA
ATAAAAGAAGATGTCATTTCTTTTATACGTTTAGGATCACATTCTGAACTTTTTGATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11055.47 Da
• Isoelectric Point: 5.8616

>AT78113 WP_261920733.1 NZ_CP022013:983025-983318 [Mergibacter septicus]
MSRSNAAFSFRVAESVKIKAFQVIEEYGLTPSQVLNLFLTEIANTKTIPVNLSYLKPNKATLEAIHEVRSGKAERYNTNT
NNFFNTIREITEEINEE

Nucleotide

• Length: 294 bp

>AT78113 NZ_CP022013:983025-983318 [Mergibacter septicus]
ATGTCTAGAAGTAATGCCGCTTTCAGTTTTCGAGTAGCTGAAAGTGTAAAAATAAAAGCTTTTCAAGTAATTGAAGAATA
TGGCTTAACGCCATCTCAAGTTTTAAATTTATTTTTAACCGAGATTGCGAATACAAAAACAATACCTGTTAATTTATCTT
ACCTTAAGCCAAACAAAGCAACCTTAGAAGCGATACACGAAGTCAGAAGTGGTAAAGCTGAACGTTATAATACTAATACA
AACAATTTTTTTAATACAATTAGAGAAATAACCGAGGAAATAAATGAAGAATGA