Detailed information of TA system TA078109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 615732..616315
• Replicon: chromosome
• Accession: NZ_CP022012
• Organism: Mergibacter septicus strain 16309-1-I1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEP49_RS02770
• Protein ID: WP_265474797.1
• Coordinates: 616046..616315 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEP49_RS02765
• Protein ID: WP_261920733.1
• Coordinates: 615732..616025 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP49_RS02750 (CEP49_02745)	611627..612934	-	1308	WP_265474791.1	histidinol dehydrogenase	-
CEP49_RS02755 (CEP49_02750)	612943..613842	-	900	WP_265474793.1	ATP phosphoribosyltransferase	-
CEP49_RS02760 (CEP49_02755)	614285..615535	+	1251	WP_265474795.1	tryptophan permease	-
CEP49_RS02765 (CEP49_02760)	615732..616025	+	294	WP_261920733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CEP49_RS02770 (CEP49_02765)	616046..616315	+	270	WP_265474797.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CEP49_RS02775 (CEP49_02770)	616627..616908	-	282	WP_265474799.1	virulence factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-86)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10340.00 Da
• Isoelectric Point: 6.2133

>T78109 WP_265474797.1 NZ_CP022012:616046-616315 [Mergibacter septicus]
MYYPNVLKKDITNLSKSHPEILISKRFTEVFNLLINGKPLPEIYKDHALSGNMQGIRDCHIYNDLILLYEIKEDVISFIR
LGSPSELFD

Nucleotide

• Length: 270 bp

>T78109 NZ_CP022012:616046-616315 [Mergibacter septicus]
ATGTATTATCCAAACGTTTTAAAAAAAGATATTACCAATTTATCAAAATCTCACCCTGAAATTTTAATTAGTAAACGTTT
TACGGAAGTTTTTAATCTATTGATAAACGGAAAGCCTCTTCCTGAAATTTATAAAGATCACGCTTTATCGGGAAATATGC
AAGGGATACGAGATTGCCATATCTATAACGATCTCATATTACTTTACGAAATAAAAGAAGATGTCATTTCTTTTATACGT
TTAGGATCACCTTCTGAACTTTTTGATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11055.47 Da
• Isoelectric Point: 5.8616

>AT78109 WP_261920733.1 NZ_CP022012:615732-616025 [Mergibacter septicus]
MSRSNAAFSFRVAESVKIKAFQVIEEYGLTPSQVLNLFLTEIANTKTIPVNLSYLKPNKATLEAIHEVRSGKAERYNTNT
NNFFNTIREITEEINEE

Nucleotide

• Length: 294 bp

>AT78109 NZ_CP022012:615732-616025 [Mergibacter septicus]
ATGTCTAGAAGTAATGCCGCTTTCAGTTTTCGAGTAGCTGAAAGTGTAAAAATAAAAGCTTTTCAAGTAATTGAAGAATA
TGGCTTAACGCCATCTCAAGTTTTAAATTTATTTTTAACCGAGATTGCGAATACAAAAACAATACCCGTTAATTTATCTT
ACCTTAAACCAAACAAAGCAACCTTAGAAGCAATACACGAAGTCAGGAGTGGTAAAGCTGAACGTTATAATACTAATACA
AACAATTTTTTTAATACGATTAGAGAAATAACCGAGGAAATAAATGAAGAATGA