Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 993029..993651 Replicon chromosome
Accession NZ_CP022011
Organism Mergibacter septicus strain 27576-1-I1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CEP48_RS04670 Protein ID WP_261920724.1
Coordinates 993469..993651 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CEP48_RS04665 Protein ID WP_261920725.1
Coordinates 993029..993433 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP48_RS04660 (CEP48_04615) 991934..992647 - 714 WP_261920726.1 phosphoribosyltransferase -
CEP48_RS04665 (CEP48_04620) 993029..993433 - 405 WP_261920725.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CEP48_RS04670 (CEP48_04625) 993469..993651 - 183 WP_261920724.1 type II toxin-antitoxin system HicA family toxin Toxin
CEP48_RS04675 (CEP48_04630) 993879..994901 - 1023 WP_261920723.1 porphobilinogen synthase -
CEP48_RS04680 (CEP48_04635) 995004..995789 - 786 WP_261920722.1 Sec-independent protein translocase subunit TatC -
CEP48_RS04685 (CEP48_04640) 995861..996469 - 609 WP_261920721.1 Sec-independent protein translocase protein TatB -
CEP48_RS04690 (CEP48_04645) 996473..996706 - 234 WP_261920720.1 Sec-independent protein translocase subunit TatA -
CEP48_RS04695 (CEP48_04650) 996803..998446 - 1644 WP_261920719.1 ubiquinone biosynthesis regulatory protein kinase UbiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6893.21 Da        Isoelectric Point: 11.1504

>T78108 WP_261920724.1 NZ_CP022011:c993651-993469 [Mergibacter septicus]
VNSATLMKLIEEDGWFLVSIKGSHHQFKHPIKKGRVTIPHPKKDLHIKTVNSILKQARLK

Download         Length: 183 bp

>T78108 NZ_CP022011:c993651-993469 [Mergibacter septicus]
GTGAACAGTGCAACGTTAATGAAACTAATTGAGGAAGATGGCTGGTTTCTTGTATCAATAAAAGGAAGTCATCATCAATT
CAAACACCCTATAAAAAAAGGACGTGTTACTATCCCTCATCCGAAAAAGGATTTACATATAAAAACAGTAAATTCAATCT
TAAAACAAGCAAGGCTAAAATAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14862.05 Da        Isoelectric Point: 4.5389

>AT78108 WP_261920725.1 NZ_CP022011:c993433-993029 [Mergibacter septicus]
MLYPIGIEMGDEKHAFSVIVPDIPGCFSAGDTLEEAFTNAKEAIAFHIAGMLEDGEEIPLPTDLQLHMNNKEYEGFTFSV
VDVDLTHLMGKTEKINITLPSLLLHKIDSFVATHPEYKNRSNFLAKIATEKVLA

Download         Length: 405 bp

>AT78108 NZ_CP022011:c993433-993029 [Mergibacter septicus]
ATGTTATATCCAATTGGAATTGAAATGGGTGATGAAAAACACGCTTTTAGTGTTATTGTACCTGATATTCCGGGTTGCTT
TTCTGCAGGCGATACATTGGAAGAAGCCTTTACAAATGCAAAAGAAGCAATAGCTTTTCATATTGCAGGTATGCTTGAGG
ACGGTGAAGAAATCCCATTGCCAACAGACCTACAACTACATATGAATAACAAAGAATATGAAGGATTTACCTTTAGCGTG
GTAGATGTTGATCTAACTCATTTAATGGGAAAAACAGAAAAAATTAATATAACCTTGCCATCATTGCTGCTCCATAAAAT
TGACAGCTTTGTTGCAACTCACCCAGAATATAAAAACCGCAGCAACTTTTTAGCCAAAATCGCCACAGAAAAAGTATTAG
CATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References