Detailed information of TA system TA078107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 983026..983608
• Replicon: chromosome
• Accession: NZ_CP022011
• Organism: Mergibacter septicus strain 27576-1-I1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEP48_RS04635
• Protein ID: WP_261920732.1
• Coordinates: 983309..983608 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEP48_RS04630
• Protein ID: WP_261920733.1
• Coordinates: 983026..983319 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP48_RS04615 (CEP48_04570)	978915..980222	-	1308	WP_261920736.1	histidinol dehydrogenase	-
CEP48_RS04620 (CEP48_04575)	980231..981130	-	900	WP_261920735.1	ATP phosphoribosyltransferase	-
CEP48_RS04625 (CEP48_04580)	981579..982829	+	1251	WP_261920734.1	tryptophan permease	-
CEP48_RS04630 (CEP48_04585)	983026..983319	+	294	WP_261920733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CEP48_RS04635 (CEP48_04590)	983309..983608	+	300	WP_261920732.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CEP48_RS04640 (CEP48_04595)	983826..984119	+	294	WP_261920731.1	DUF1778 domain-containing protein	-
CEP48_RS04645 (CEP48_04600)	984116..984634	+	519	WP_261920730.1	GNAT family N-acetyltransferase	-
CEP48_RS04650 (CEP48_04605)	984761..986698	-	1938	WP_265490190.1	YadA-like family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (13-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-86)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11566.36 Da
• Isoelectric Point: 8.0629

>T78107 WP_261920732.1 NZ_CP022011:983309-983608 [Mergibacter septicus]
MKNESNKVQNYVLSKRFKKDITNLSKSHPEILISKRFTEVFNLLINGKPLPEIYKDHALSGNMQGIRDCHIYNDLILLYE
IKEDVISFIRLGSHSELFD

Nucleotide

• Length: 300 bp

>T78107 NZ_CP022011:983309-983608 [Mergibacter septicus]
ATGAAGAATGAATCGAATAAAGTTCAGAATTATGTATTATCCAAACGTTTTAAAAAAGATATTACCAATTTATCAAAATC
TCACCCTGAAATTTTAATTAGTAAACGTTTTACGGAAGTTTTTAATCTATTGATAAACGGAAAGCCTCTTCCTGAAATTT
ATAAAGATCACGCTTTATCGGGAAATATGCAAGGGATACGAGATTGCCATATCTATAACGATCTCATATTACTTTACGAA
ATAAAAGAAGATGTCATTTCTTTTATACGTTTAGGATCACATTCTGAACTTTTTGATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11055.47 Da
• Isoelectric Point: 5.8616

>AT78107 WP_261920733.1 NZ_CP022011:983026-983319 [Mergibacter septicus]
MSRSNAAFSFRVAESVKIKAFQVIEEYGLTPSQVLNLFLTEIANTKTIPVNLSYLKPNKATLEAIHEVRSGKAERYNTNT
NNFFNTIREITEEINEE

Nucleotide

• Length: 294 bp

>AT78107 NZ_CP022011:983026-983319 [Mergibacter septicus]
ATGTCTAGAAGTAATGCCGCTTTCAGTTTTCGAGTAGCTGAAAGTGTAAAAATAAAAGCTTTTCAAGTAATTGAAGAATA
TGGCTTAACGCCATCTCAAGTTTTAAATTTATTTTTAACCGAGATTGCGAATACAAAAACAATACCTGTTAATTTATCTT
ACCTTAAGCCAAACAAAGCAACCTTAGAAGCGATACACGAAGTCAGAAGTGGTAAAGCTGAACGTTATAATACTAATACA
AACAATTTTTTTAATACAATTAGAGAAATAACCGAGGAAATAAATGAAGAATGA