Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 565581..566313 Replicon chromosome
Accession NZ_CP022011
Organism Mergibacter septicus strain 27576-1-I1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag CEP48_RS02720 Protein ID WP_261919529.1
Coordinates 565581..566048 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag CEP48_RS02725 Protein ID WP_261919528.1
Coordinates 566050..566313 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP48_RS02705 (CEP48_02690) 561993..563066 + 1074 WP_261921000.1 alanine racemase -
CEP48_RS02710 (CEP48_02695) 563083..564732 + 1650 WP_261919531.1 glucose-6-phosphate isomerase -
CEP48_RS02715 (CEP48_02700) 564805..565332 - 528 WP_261919530.1 peptide-methionine (S)-S-oxide reductase MsrA -
CEP48_RS02720 (CEP48_02705) 565581..566048 - 468 WP_261919529.1 GNAT family N-acetyltransferase Toxin
CEP48_RS02725 (CEP48_02710) 566050..566313 - 264 WP_261919528.1 DUF1778 domain-containing protein Antitoxin
CEP48_RS02730 (CEP48_02715) 566532..569390 - 2859 WP_261919527.1 valine--tRNA ligase -
CEP48_RS02735 (CEP48_02720) 569427..569873 - 447 WP_261919526.1 DNA polymerase III subunit chi -
CEP48_RS02740 (CEP48_02725) 570011..570622 - 612 WP_261919525.1 recombination mediator RecR -
CEP48_RS02745 (CEP48_02730) 570666..570995 - 330 WP_261919524.1 YbaB/EbfC family nucleoid-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17426.33 Da        Isoelectric Point: 10.1606

>T78106 WP_261919529.1 NZ_CP022011:c566048-565581 [Mergibacter septicus]
MYSAPELLTHNHRLDFFDCGEESLNIWLRRNALKNQQNQASRTFVICKENIVVGFYALAAGAVTHQFASSTLRRNMPEPI
PVVVLGRLAIDVKHQGKKLGAALLKDVVLRSKSISEQIGVRALLVHALNNKAKQFYLHYGFQPSPIDDMSLMLKL

Download         Length: 468 bp

>T78106 NZ_CP022011:c566048-565581 [Mergibacter septicus]
ATGTATTCAGCACCTGAATTACTAACGCATAATCATCGTCTAGATTTCTTTGATTGCGGAGAAGAATCATTAAATATATG
GCTTAGACGAAATGCACTTAAAAATCAACAAAACCAAGCAAGTAGAACATTTGTGATCTGTAAGGAAAATATTGTTGTTG
GTTTTTATGCTTTAGCAGCAGGGGCGGTTACTCATCAATTTGCATCAAGTACATTAAGACGTAATATGCCAGAACCTATC
CCTGTCGTTGTTTTAGGGCGATTAGCCATAGATGTAAAACATCAAGGAAAAAAATTAGGTGCTGCACTACTCAAAGATGT
TGTGTTAAGATCGAAATCCATATCAGAACAAATTGGAGTAAGGGCATTGCTAGTTCATGCTTTGAATAATAAAGCAAAGC
AATTCTATTTACATTATGGTTTTCAACCATCTCCAATTGATGATATGTCACTAATGTTGAAGTTGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9916.59 Da        Isoelectric Point: 6.2649

>AT78106 WP_261919528.1 NZ_CP022011:c566313-566050 [Mergibacter septicus]
MRTAAINLRAKPMQRDLIDQAAALLGKTRSDFMLDAACTYAQNVILERTVFQLSEEKFNCFIEVLEQPNIANTKLEKLMA
IKSPWEV

Download         Length: 264 bp

>AT78106 NZ_CP022011:c566313-566050 [Mergibacter septicus]
ATGCGTACCGCTGCAATTAATTTACGAGCCAAACCAATGCAACGTGATTTGATCGATCAAGCTGCTGCATTATTAGGCAA
AACACGTTCTGATTTTATGCTAGATGCGGCTTGTACCTATGCACAAAACGTCATTTTAGAGAGAACAGTATTTCAATTAA
GTGAAGAGAAATTTAACTGTTTTATTGAGGTACTAGAACAACCTAACATCGCTAATACTAAATTAGAAAAATTAATGGCT
ATTAAATCCCCTTGGGAAGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References