Detailed information of TA system TA078103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1804722..1805317
• Replicon: chromosome
• Accession: NZ_CP022010
• Organism: Mergibacter septicus strain 27643-20-I1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CEP45_RS08215
• Protein ID: WP_265490661.1
• Coordinates: 1804722..1804970 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CEP45_RS08220
• Protein ID: WP_265490662.1
• Coordinates: 1804967..1805317 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP45_RS08170	1800676..1800918	-	243	WP_265490654.1	tyrosine-type recombinase/integrase	-
CEP45_RS08175 (CEP45_08140)	1801155..1801310	-	156	WP_265490655.1	helix-turn-helix domain-containing protein	-
CEP45_RS08180 (CEP45_08145)	1801334..1802071	-	738	WP_265490656.1	phage recombination protein Bet	-
CEP45_RS08185 (CEP45_08150)	1802278..1802607	-	330	Protein_1562	bacteriocin	-
CEP45_RS08190	1802621..1802800	-	180	WP_265490657.1	hypothetical protein	-
CEP45_RS08195 (CEP45_08155)	1802928..1803356	-	429	WP_265490658.1	type II toxin-antitoxin system HicB family antitoxin	-
CEP45_RS08200 (CEP45_08160)	1803387..1803572	-	186	WP_265490659.1	type II toxin-antitoxin system HicA family toxin	-
CEP45_RS08205 (CEP45_08165)	1803658..1804236	+	579	Protein_1566	recombination protein NinG	-
CEP45_RS08210 (CEP45_08170)	1804236..1804640	+	405	WP_265490660.1	hypothetical protein	-
CEP45_RS08215 (CEP45_08175)	1804722..1804970	+	249	WP_265490661.1	type II toxin-antitoxin system HicA family toxin	Toxin
CEP45_RS08220 (CEP45_08180)	1804967..1805317	+	351	WP_265490662.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CEP45_RS08225 (CEP45_08185)	1805465..1805701	+	237	WP_265490663.1	hypothetical protein	-
CEP45_RS08230 (CEP45_08190)	1805950..1806588	-	639	WP_265490664.1	nitroreductase family protein	-
CEP45_RS08235 (CEP45_08195)	1806612..1807793	-	1182	WP_265490665.1	iron-containing alcohol dehydrogenase	-
CEP45_RS08240 (CEP45_08200)	1807876..1808466	-	591	WP_265490666.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1800818..1810321	9503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-78)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9177.86 Da
• Isoelectric Point: 10.3381

>T78103 WP_265490661.1 NZ_CP022010:1804722-1804970 [Mergibacter septicus]
MGKSEKLLEKLANAKTTFVWGDLLTLLARLGYEKKEMAGSRVRFYNVEKDHLILLHKPHPENYIKGGALKSVKDGLKGVG
LL

Nucleotide

• Length: 249 bp

>T78103 NZ_CP022010:1804722-1804970 [Mergibacter septicus]
ATGGGCAAATCAGAAAAATTATTAGAAAAACTCGCAAATGCAAAAACAACCTTTGTATGGGGTGATTTGCTTACTTTACT
GGCTCGTTTAGGCTATGAGAAAAAAGAGATGGCTGGTTCCCGAGTGCGTTTTTATAATGTGGAAAAAGATCATTTAATTT
TATTACATAAACCGCATCCTGAAAATTATATTAAAGGTGGTGCATTAAAATCAGTTAAAGATGGTTTGAAAGGAGTTGGC
TTATTATGA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 13289.18 Da
• Isoelectric Point: 4.8118

>AT78103 WP_265490662.1 NZ_CP022010:1804967-1805317 [Mergibacter septicus]
MTFLKYKGYVGTIEADLENNVLFGKLAYLRDLITYEAETLPELEKEFRTSVDMYLQDCEELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGELSLNAFVSEAIKEKVERSQLIHKTT

Nucleotide

• Length: 351 bp

>AT78103 NZ_CP022010:1804967-1805317 [Mergibacter septicus]
ATGACATTTCTAAAATATAAAGGGTATGTTGGCACAATAGAGGCAGATTTAGAAAATAATGTTCTTTTTGGTAAATTGGC
GTATTTACGTGATCTGATTACCTATGAGGCGGAAACATTGCCTGAGTTAGAAAAAGAGTTTAGGACCTCAGTAGATATGT
ATTTACAAGATTGTGAGGAGTTGGGTCGCACACCTGATAAACCGTTTAAAGGTGTATTTAATGTACGTATCAGTGAAGAG
CTTCATCGTAATGCAGTGCTCGCAGCGGGTGAATTAAGTTTAAATGCTTTCGTGAGTGAGGCTATTAAGGAAAAAGTTGA
ACGTTCTCAATTAATTCATAAAACTACTTGA