Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1802928..1803572 | Replicon | chromosome |
| Accession | NZ_CP022010 | ||
| Organism | Mergibacter septicus strain 27643-20-I1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | CEP45_RS08200 | Protein ID | WP_265490659.1 |
| Coordinates | 1803387..1803572 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | CEP45_RS08195 | Protein ID | WP_265490658.1 |
| Coordinates | 1802928..1803356 (-) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEP45_RS08160 (CEP45_08125) | 1798937..1800382 | + | 1446 | WP_265490653.1 | glutamate--tRNA ligase | - |
| CEP45_RS08170 | 1800676..1800918 | - | 243 | WP_265490654.1 | tyrosine-type recombinase/integrase | - |
| CEP45_RS08175 (CEP45_08140) | 1801155..1801310 | - | 156 | WP_265490655.1 | helix-turn-helix domain-containing protein | - |
| CEP45_RS08180 (CEP45_08145) | 1801334..1802071 | - | 738 | WP_265490656.1 | phage recombination protein Bet | - |
| CEP45_RS08185 (CEP45_08150) | 1802278..1802607 | - | 330 | Protein_1562 | bacteriocin | - |
| CEP45_RS08190 | 1802621..1802800 | - | 180 | WP_265490657.1 | hypothetical protein | - |
| CEP45_RS08195 (CEP45_08155) | 1802928..1803356 | - | 429 | WP_265490658.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| CEP45_RS08200 (CEP45_08160) | 1803387..1803572 | - | 186 | WP_265490659.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| CEP45_RS08205 (CEP45_08165) | 1803658..1804236 | + | 579 | Protein_1566 | recombination protein NinG | - |
| CEP45_RS08210 (CEP45_08170) | 1804236..1804640 | + | 405 | WP_265490660.1 | hypothetical protein | - |
| CEP45_RS08215 (CEP45_08175) | 1804722..1804970 | + | 249 | WP_265490661.1 | type II toxin-antitoxin system HicA family toxin | - |
| CEP45_RS08220 (CEP45_08180) | 1804967..1805317 | + | 351 | WP_265490662.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| CEP45_RS08225 (CEP45_08185) | 1805465..1805701 | + | 237 | WP_265490663.1 | hypothetical protein | - |
| CEP45_RS08230 (CEP45_08190) | 1805950..1806588 | - | 639 | WP_265490664.1 | nitroreductase family protein | - |
| CEP45_RS08235 (CEP45_08195) | 1806612..1807793 | - | 1182 | WP_265490665.1 | iron-containing alcohol dehydrogenase | - |
| CEP45_RS08240 (CEP45_08200) | 1807876..1808466 | - | 591 | WP_265490666.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1800818..1810321 | 9503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6820.99 Da Isoelectric Point: 10.7852
>T78102 WP_265490659.1 NZ_CP022010:c1803572-1803387 [Mergibacter septicus]
MHSRDLIKELKDAGCTFIRHGKGDHQIWQSPITGKIFPVPHPKQHVPIGTLRSIQKSAGLL
MHSRDLIKELKDAGCTFIRHGKGDHQIWQSPITGKIFPVPHPKQHVPIGTLRSIQKSAGLL
Download Length: 186 bp
>T78102 NZ_CP022010:c1803572-1803387 [Mergibacter septicus]
ATGCACTCACGCGACTTAATCAAGGAACTTAAAGATGCAGGTTGCACGTTTATTCGGCACGGTAAAGGCGATCACCAAAT
TTGGCAGTCGCCCATTACAGGAAAAATATTTCCCGTACCACACCCAAAGCAACACGTTCCAATCGGCACATTAAGATCCA
TCCAAAAATCGGCAGGGCTTTTATAG
ATGCACTCACGCGACTTAATCAAGGAACTTAAAGATGCAGGTTGCACGTTTATTCGGCACGGTAAAGGCGATCACCAAAT
TTGGCAGTCGCCCATTACAGGAAAAATATTTCCCGTACCACACCCAAAGCAACACGTTCCAATCGGCACATTAAGATCCA
TCCAAAAATCGGCAGGGCTTTTATAG
Antitoxin
Download Length: 143 a.a. Molecular weight: 16245.33 Da Isoelectric Point: 4.3994
>AT78102 WP_265490658.1 NZ_CP022010:c1803356-1802928 [Mergibacter septicus]
MLFTIGIETPDNENEAYGIAVPVLFTDKYACISAADALEEIPVQATDAIHSILEIMFEDGTNISELQDKGYKHYQTLEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRE
MLFTIGIETPDNENEAYGIAVPVLFTDKYACISAADALEEIPVQATDAIHSILEIMFEDGTNISELQDKGYKHYQTLEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRE
Download Length: 429 bp
>AT78102 NZ_CP022010:c1803356-1802928 [Mergibacter septicus]
ATGTTATTTACTATCGGCATTGAAACCCCTGATAACGAAAATGAAGCTTACGGCATTGCCGTGCCAGTATTATTTACAGA
TAAATACGCTTGCATTAGTGCAGCAGATGCGCTTGAAGAAATTCCAGTGCAAGCAACAGACGCCATTCATTCCATCTTAG
AAATAATGTTTGAAGACGGCACAAATATCAGTGAGCTTCAAGATAAAGGCTATAAGCACTACCAAACCTTAGAAGACTTT
AACTACTGCGATACTTGGTTACTGCTTGATGTGGATATTTCCGCTTATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCCGAATATCTCATCAAACGCATTGATAGCCGTGTAGCAAGCAACCCAATTTATAAAGATCGTAGTCATTTTTTAGCTA
TTGCTTCACAAAAAGAGCTACGAGAATAA
ATGTTATTTACTATCGGCATTGAAACCCCTGATAACGAAAATGAAGCTTACGGCATTGCCGTGCCAGTATTATTTACAGA
TAAATACGCTTGCATTAGTGCAGCAGATGCGCTTGAAGAAATTCCAGTGCAAGCAACAGACGCCATTCATTCCATCTTAG
AAATAATGTTTGAAGACGGCACAAATATCAGTGAGCTTCAAGATAAAGGCTATAAGCACTACCAAACCTTAGAAGACTTT
AACTACTGCGATACTTGGTTACTGCTTGATGTGGATATTTCCGCTTATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCCGAATATCTCATCAAACGCATTGATAGCCGTGTAGCAAGCAACCCAATTTATAAAGATCGTAGTCATTTTTTAGCTA
TTGCTTCACAAAAAGAGCTACGAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|