Detailed information of TA system TA078093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 50812..51337
• Replicon: plasmid pCFSAN051873
• Accession: NZ_CP022004
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051873

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: BCA92_RS24145
• Protein ID: WP_001159863.1
• Coordinates: 51032..51337 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: BCA92_RS24140
• Protein ID: WP_000813641.1
• Coordinates: 50812..51030 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCA92_RS24110	46426..46812	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
BCA92_RS24115	46865..47026	+	162	WP_015059604.1	hypothetical protein	-
BCA92_RS24120	47353..48342	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
BCA92_RS24125	48836..49131	-	296	Protein_61	cytoplasmic protein	-
BCA92_RS24530	49143..49571	+	429	Protein_62	hypothetical protein	-
BCA92_RS24135	49615..50136	-	522	WP_077681952.1	hypothetical protein	-
BCA92_RS24140	50812..51030	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
BCA92_RS24145	51032..51337	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
BCA92_RS24150	51339..51629	+	291	WP_001266176.1	hypothetical protein	-
BCA92_RS24155	51626..52147	+	522	WP_000198608.1	hypothetical protein	-
BCA92_RS24160	52182..52964	+	783	WP_000082169.1	site-specific integrase	-
BCA92_RS24165	52973..53686	+	714	WP_000545756.1	EAL domain-containing protein	-
BCA92_RS24170	53690..54199	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
BCA92_RS24175	54193..54678	+	486	WP_000905606.1	membrane protein	-
BCA92_RS24180	54955..55242	-	288	WP_071530243.1	hypothetical protein	-
BCA92_RS24185	55398..55958	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59371	59371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (159-408)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T78093 WP_001159863.1 NZ_CP022004:51032-51337 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T78093 NZ_CP022004:51032-51337 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT78093 WP_000813641.1 NZ_CP022004:50812-51030 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT78093 NZ_CP022004:50812-51030 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6