Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relB-parE/RHH(antitoxin) |
Location | 4711202..4711755 | Replicon | chromosome |
Accession | NZ_CP022002 | ||
Organism | Pseudomonas aeruginosa strain Pa1242 |
Toxin (Protein)
Gene name | parE | Uniprot ID | Q88JZ3 |
Locus tag | CD799_RS22345 | Protein ID | WP_010953434.1 |
Coordinates | 4711202..4711495 (-) | Length | 98 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q88JZ4 |
Locus tag | CD799_RS22350 | Protein ID | WP_010953433.1 |
Coordinates | 4711483..4711755 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CD799_RS22325 | 4706553..4707440 | - | 888 | WP_088376753.1 | hypothetical protein | - |
CD799_RS22335 | 4708293..4709492 | + | 1200 | WP_088376754.1 | tyrosine-type recombinase/integrase | - |
CD799_RS22340 | 4709799..4711208 | + | 1410 | WP_010953435.1 | site-specific integrase | - |
CD799_RS22345 | 4711202..4711495 | - | 294 | WP_010953434.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CD799_RS22350 | 4711483..4711755 | - | 273 | WP_010953433.1 | CopG family ribbon-helix-helix protein | Antitoxin |
CD799_RS22355 | 4711880..4712125 | - | 246 | WP_010953432.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
CD799_RS22360 | 4712387..4712659 | + | 273 | WP_031299398.1 | hypothetical protein | - |
CD799_RS22365 | 4712757..4713725 | + | 969 | WP_031299399.1 | DUF932 domain-containing protein | - |
CD799_RS22370 | 4713805..4714809 | + | 1005 | WP_041506095.1 | YqaJ viral recombinase family protein | - |
CD799_RS22375 | 4714902..4715045 | + | 144 | Protein_4326 | hydrolase or metal-binding protein | - |
CD799_RS22380 | 4715043..4715813 | - | 771 | WP_088376756.1 | dioxygenase | - |
CD799_RS22385 | 4715834..4716463 | - | 630 | WP_041506111.1 | NADPH-dependent F420 reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11155.61 Da Isoelectric Point: 5.9081
>T78091 WP_010953434.1 NZ_CP022002:c4711495-4711202 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY
Download Length: 294 bp
>T78091 NZ_CP022002:c4711495-4711202 [Pseudomonas aeruginosa]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10373.53 Da Isoelectric Point: 5.5744
>AT78091 WP_010953433.1 NZ_CP022002:c4711755-4711483 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD
Download Length: 273 bp
>AT78091 NZ_CP022002:c4711755-4711483 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2W5CNE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q88JZ4 |