Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4711202..4711755 Replicon chromosome
Accession NZ_CP022002
Organism Pseudomonas aeruginosa strain Pa1242

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag CD799_RS22345 Protein ID WP_010953434.1
Coordinates 4711202..4711495 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag CD799_RS22350 Protein ID WP_010953433.1
Coordinates 4711483..4711755 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD799_RS22325 4706553..4707440 - 888 WP_088376753.1 hypothetical protein -
CD799_RS22335 4708293..4709492 + 1200 WP_088376754.1 tyrosine-type recombinase/integrase -
CD799_RS22340 4709799..4711208 + 1410 WP_010953435.1 site-specific integrase -
CD799_RS22345 4711202..4711495 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CD799_RS22350 4711483..4711755 - 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
CD799_RS22355 4711880..4712125 - 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CD799_RS22360 4712387..4712659 + 273 WP_031299398.1 hypothetical protein -
CD799_RS22365 4712757..4713725 + 969 WP_031299399.1 DUF932 domain-containing protein -
CD799_RS22370 4713805..4714809 + 1005 WP_041506095.1 YqaJ viral recombinase family protein -
CD799_RS22375 4714902..4715045 + 144 Protein_4326 hydrolase or metal-binding protein -
CD799_RS22380 4715043..4715813 - 771 WP_088376756.1 dioxygenase -
CD799_RS22385 4715834..4716463 - 630 WP_041506111.1 NADPH-dependent F420 reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T78091 WP_010953434.1 NZ_CP022002:c4711495-4711202 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T78091 NZ_CP022002:c4711495-4711202 [Pseudomonas aeruginosa]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT78091 WP_010953433.1 NZ_CP022002:c4711755-4711483 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT78091 NZ_CP022002:c4711755-4711483 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References