Detailed information of TA system TA078087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PfiT-PfiA/ParE(toxin)
• Location: 2178164..2178772
• Replicon: chromosome
• Accession: NZ_CP022002
• Organism: Pseudomonas aeruginosa strain Pa1242

Toxin (Protein)

• Gene name: PfiT
• Uniprot ID: -
• Locus tag: CD799_RS10275
• Protein ID: WP_016263850.1
• Coordinates: 2178425..2178772 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: PfiA
• Uniprot ID: A0A0B0C355
• Locus tag: CD799_RS10270
• Protein ID: WP_003114155.1
• Coordinates: 2178164..2178415 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD799_RS10250	2173802..2174152	+	351	WP_019725830.1	DUF2523 domain-containing protein	-
CD799_RS10255	2174154..2175416	+	1263	WP_019725831.1	hypothetical protein	-
CD799_RS10260	2175675..2176967	+	1293	WP_003115206.1	hypothetical protein	-
CD799_RS10265	2176967..2177950	+	984	WP_019725833.1	tyrosine-type recombinase/integrase	-
CD799_RS10270	2178164..2178415	+	252	WP_003114155.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CD799_RS10275	2178425..2178772	+	348	WP_016263850.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CD799_RS10280	2179091..2180293	+	1203	WP_034075497.1	integrase family protein	-
CD799_RS33845	2180309..2180929	+	621	WP_124207766.1	hypothetical protein	-
CD799_RS10285	2180926..2181132	-	207	WP_033989513.1	AlpA family phage regulatory protein	-
CD799_RS10290	2181122..2181526	-	405	WP_058171606.1	hypothetical protein	-
CD799_RS10295	2181523..2181906	-	384	WP_088376624.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2164241..2215131	50890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13046.85 Da
• Isoelectric Point: 4.4212

>T78087 WP_016263850.1 NZ_CP022002:2178425-2178772 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Nucleotide

• Length: 348 bp

>T78087 NZ_CP022002:2178425-2178772 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9442.79 Da
• Isoelectric Point: 9.4808

>AT78087 WP_003114155.1 NZ_CP022002:2178164-2178415 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Nucleotide

• Length: 252 bp

>AT78087 NZ_CP022002:2178164-2178415 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACTTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0B0C355