78083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5317375..5318417 Replicon chromosome
Accession NZ_CP022001
Organism Pseudomonas aeruginosa strain Pa1207

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CD800_RS25560 Protein ID WP_003153636.1
Coordinates 5317375..5317950 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag CD800_RS25565 Protein ID WP_003050245.1
Coordinates 5317947..5318417 (-) Length 157 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD800_RS25535 5313813..5314538 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
CD800_RS25540 5314577..5315479 - 903 WP_003090158.1 nucleotidyltransferase domain-containing protein -
CD800_RS25545 5315479..5315979 - 501 WP_003090159.1 hypothetical protein -
CD800_RS25550 5315976..5316446 - 471 WP_003090160.1 hypothetical protein -
CD800_RS25555 5316443..5317357 - 915 WP_016852809.1 AAA family ATPase -
CD800_RS25560 5317375..5317950 - 576 WP_003153636.1 PIN domain-containing protein Toxin
CD800_RS25565 5317947..5318417 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
CD800_RS25570 5318621..5319004 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
CD800_RS25575 5319001..5319234 + 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
CD800_RS25580 5319251..5319610 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
CD800_RS25585 5319622..5320020 + 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
CD800_RS25590 5320017..5320709 + 693 WP_023100424.1 TIGR03746 family integrating conjugative element protein -
CD800_RS25595 5320706..5321617 + 912 WP_023100423.1 TIGR03749 family integrating conjugative element protein -
CD800_RS25600 5321607..5323025 + 1419 WP_023100422.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5150139..5332109 181970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-114)

Antitoxin

(85-133)


Sequences


Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T78083 WP_003153636.1 NZ_CP022001:c5317950-5317375 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T78083 NZ_CP022001:c5317950-5317375 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAATGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT78083 WP_003050245.1 NZ_CP022001:c5318417-5317947 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT78083 NZ_CP022001:c5318417-5317947 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References