Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4976660..4977213 Replicon chromosome
Accession NZ_CP022001
Organism Pseudomonas aeruginosa strain Pa1207

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag CD800_RS23685 Protein ID WP_010953434.1
Coordinates 4976660..4976953 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2W5CWX7
Locus tag CD800_RS23690 Protein ID WP_017940300.1
Coordinates 4976941..4977213 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD800_RS36090 4973160..4973303 + 144 Protein_4586 type I toxin-antitoxin system SymE family toxin -
CD800_RS23670 4973370..4974532 + 1163 WP_086008657.1 IS3 family transposase -
CD800_RS23680 4975257..4976666 + 1410 WP_070087258.1 site-specific integrase -
CD800_RS23685 4976660..4976953 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CD800_RS23690 4976941..4977213 - 273 WP_017940300.1 CopG family ribbon-helix-helix protein Antitoxin
CD800_RS23695 4977339..4977584 - 246 WP_070087259.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CD800_RS23700 4977789..4978118 + 330 WP_058164160.1 hypothetical protein -
CD800_RS23705 4978216..4979184 + 969 WP_045633504.1 DUF932 domain-containing protein -
CD800_RS23710 4979259..4980263 + 1005 WP_070087260.1 YqaJ viral recombinase family protein -
CD800_RS23715 4980341..4981255 + 915 WP_070087261.1 hydrolase or metal-binding protein -
CD800_RS23720 4981305..4981802 + 498 WP_070087262.1 DNA repair protein RadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4971646..4991770 20124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T78082 WP_010953434.1 NZ_CP022001:c4976953-4976660 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T78082 NZ_CP022001:c4976953-4976660 [Pseudomonas aeruginosa]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCATTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10327.45 Da        Isoelectric Point: 5.5751

>AT78082 WP_017940300.1 NZ_CP022001:c4977213-4976941 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLAGLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT78082 NZ_CP022001:c4977213-4976941 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTGGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB A0A2W5CWX7

References