78077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 2208815..2209423 Replicon chromosome
Accession NZ_CP022001
Organism Pseudomonas aeruginosa strain Pa1207

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag CD800_RS10485 Protein ID WP_003123043.1
Coordinates 2209076..2209423 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag CD800_RS10480 Protein ID WP_003114155.1
Coordinates 2208815..2209066 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD800_RS10455 2203838..2204443 + 606 WP_014603242.1 hypothetical protein -
CD800_RS10460 2204453..2204803 + 351 WP_003159569.1 DUF2523 domain-containing protein -
CD800_RS10465 2204805..2206067 + 1263 WP_023093179.1 hypothetical protein -
CD800_RS10470 2206326..2207618 + 1293 WP_003115206.1 hypothetical protein -
CD800_RS10475 2207618..2208601 + 984 WP_016852062.1 tyrosine-type recombinase/integrase -
CD800_RS10480 2208815..2209066 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CD800_RS10485 2209076..2209423 + 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CD800_RS10495 2209750..2210652 - 903 WP_014603238.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
CD800_RS10500 2211104..2211841 - 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
CD800_RS10505 2211921..2212964 - 1044 WP_003098363.1 L,D-transpeptidase -
CD800_RS10510 2213100..2213792 - 693 WP_016851968.1 16S rRNA pseudouridine(516) synthase -
CD800_RS10515 2213792..2214064 - 273 WP_016851967.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2193802..2209423 15621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T78077 WP_003123043.1 NZ_CP022001:2209076-2209423 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T78077 NZ_CP022001:2209076-2209423 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT78077 WP_003114155.1 NZ_CP022001:2208815-2209066 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT78077 NZ_CP022001:2208815-2209066 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References