78067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 200272..200777 Replicon chromosome
Accession NZ_CP022000
Organism Pseudomonas aeruginosa strain Pa127

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CD797_RS00965 Protein ID WP_003083773.1
Coordinates 200272..200553 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CD797_RS00970 Protein ID WP_003083775.1
Coordinates 200550..200777 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD797_RS00940 195523..196872 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
CD797_RS00945 196921..197607 + 687 WP_003083762.1 FadR family transcriptional regulator -
CD797_RS00950 197708..198442 + 735 WP_003083764.1 GntR family transcriptional regulator -
CD797_RS00955 198646..199032 + 387 WP_003083767.1 aegerolysin family protein -
CD797_RS00960 199064..199972 - 909 WP_003083769.1 LysR family transcriptional regulator -
CD797_RS00965 200272..200553 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CD797_RS00970 200550..200777 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CD797_RS00975 200953..201573 - 621 WP_003101226.1 hypothetical protein -
CD797_RS00980 201674..202174 + 501 WP_003083778.1 LEA type 2 family protein -
CD797_RS00985 202247..202588 + 342 WP_014603467.1 alkylphosphonate utilization protein -
CD797_RS00990 202672..204099 - 1428 WP_003083784.1 GABA permease -
CD797_RS00995 204268..205761 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T78067 WP_003083773.1 NZ_CP022000:c200553-200272 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T78067 NZ_CP022000:c200553-200272 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT78067 WP_003083775.1 NZ_CP022000:c200777-200550 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT78067 NZ_CP022000:c200777-200550 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References