Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 168013..168518 Replicon chromosome
Accession NZ_CP021999
Organism Pseudomonas aeruginosa strain Pa84

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CD796_RS00765 Protein ID WP_003083773.1
Coordinates 168013..168294 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag CD796_RS00770 Protein ID WP_003112628.1
Coordinates 168291..168518 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD796_RS00740 163264..164613 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
CD796_RS00745 164662..165348 + 687 WP_003083762.1 FadR family transcriptional regulator -
CD796_RS00750 165449..166183 + 735 WP_003117208.1 GntR family transcriptional regulator -
CD796_RS00755 166387..166773 + 387 WP_014602345.1 aegerolysin family protein -
CD796_RS00760 166805..167713 - 909 WP_003083769.1 LysR family transcriptional regulator -
CD796_RS00765 168013..168294 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CD796_RS00770 168291..168518 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
CD796_RS00775 168694..169314 - 621 WP_003101226.1 hypothetical protein -
CD796_RS00780 169415..169915 + 501 WP_003112629.1 LEA type 2 family protein -
CD796_RS00785 169988..170329 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CD796_RS00790 170411..171838 - 1428 WP_003083784.1 GABA permease -
CD796_RS00795 172007..173500 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T78060 WP_003083773.1 NZ_CP021999:c168294-168013 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T78060 NZ_CP021999:c168294-168013 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT78060 WP_003112628.1 NZ_CP021999:c168518-168291 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT78060 NZ_CP021999:c168518-168291 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References