Detailed information of TA system TA078058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 3743804..3744278
• Replicon: chromosome
• Accession: NZ_CP021983
• Organism: Halomicronema hongdechloris C2206

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: XM38_RS16995
• Protein ID: WP_080806606.1
• Coordinates: 3744117..3744278 (-)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: XM38_RS16990
• Protein ID: WP_080806608.1
• Coordinates: 3743804..3744106 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XM38_RS16950	3738831..3740291	-	1461	WP_088430494.1	PLP-dependent aminotransferase family protein	-
XM38_RS16955	3740414..3741064	+	651	WP_202979051.1	pyridoxamine 5'-phosphate oxidase family protein	-
XM38_RS16960	3741133..3741573	+	441	WP_088430496.1	gamma-glutamylcyclotransferase	-
XM38_RS16965	3741608..3741998	+	391	Protein_3385	RidA family protein	-
XM38_RS26070	3741936..3742301	-	366	WP_187329584.1	hypothetical protein	-
XM38_RS16975	3742298..3742678	-	381	WP_080806612.1	HEPN domain-containing protein	-
XM38_RS16980	3742675..3743043	-	369	WP_080806611.1	nucleotidyltransferase domain-containing protein	-
XM38_RS16985	3743072..3743680	-	609	WP_080806610.1	Uma2 family endonuclease	-
XM38_RS16990	3743804..3744106	-	303	WP_080806608.1	putative addiction module antidote protein	Antitoxin
XM38_RS16995	3744117..3744278	-	162	WP_080806606.1	addiction module killer protein	Toxin
XM38_RS17000	3744493..3744978	-	486	WP_080806604.1	hypothetical protein	-
XM38_RS17005	3745696..3745941	-	246	WP_080806600.1	hypothetical protein	-
XM38_RS17010	3745925..3746200	-	276	WP_080806598.1	BrnT family toxin	-
XM38_RS17020	3746694..3747809	+	1116	WP_088430498.1	IS66 family transposase	-
XM38_RS17025	3747939..3748151	+	213	WP_080806597.1	hypothetical protein	-
XM38_RS17030	3748747..3748995	+	249	WP_137455151.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3746694..3747809	1115

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-52)

Antitoxin

• Uncharacterized protein HI1420 (7-92)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5991.93 Da
• Isoelectric Point: 9.5923

>T78058 WP_080806606.1 NZ_CP021983:c3744278-3744117 [Halomicronema hongdechloris C2206]
VGQGVSELRINYGPEYRVYFIQRGETLVILLAEGDNKTQKRDIKAALELAKKV

Nucleotide

• Length: 162 bp

>T78058 NZ_CP021983:c3744278-3744117 [Halomicronema hongdechloris C2206]
GTGGGTCAAGGCGTCTCAGAACTACGGATTAACTATGGCCCAGAGTATCGGGTGTATTTCATCCAACGTGGCGAGACCTT
AGTCATCCTTTTAGCAGAAGGCGATAACAAGACTCAAAAACGCGATATTAAAGCAGCCTTGGAACTAGCGAAAAAGGTAT
AG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10828.31 Da
• Isoelectric Point: 4.4354

>AT78058 WP_080806608.1 NZ_CP021983:c3744106-3743804 [Halomicronema hongdechloris C2206]
MTKLQTYPWDASDHLETQEDIIAYLQAALEEDDPSLVTAALGDIARSKGMTQLAQATGLGRESLYKALSREGNPEFATVL
KVLRALGLRLQVVAVAVQEG

Nucleotide

• Length: 303 bp

>AT78058 NZ_CP021983:c3744106-3743804 [Halomicronema hongdechloris C2206]
ATGACCAAACTACAAACCTATCCTTGGGATGCGTCCGACCATCTAGAAACCCAGGAAGATATCATTGCCTATTTGCAAGC
AGCGCTAGAAGAAGACGATCCCAGCCTTGTGACAGCGGCGTTAGGCGATATTGCGCGTTCTAAAGGCATGACCCAGCTCG
CCCAGGCAACCGGATTAGGGCGTGAAAGTCTTTATAAAGCCCTATCGAGGGAAGGTAACCCAGAGTTTGCCACTGTGCTT
AAGGTTTTGCGAGCCTTAGGCTTACGTTTGCAAGTTGTCGCGGTTGCTGTTCAAGAGGGCTAA