Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1088031..1088614 Replicon chromosome
Accession NZ_CP021983
Organism Halomicronema hongdechloris C2206

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag XM38_RS05030 Protein ID WP_080806330.1
Coordinates 1088031..1088378 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag XM38_RS05035 Protein ID WP_080806331.1
Coordinates 1088372..1088614 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM38_RS04995 1083379..1083627 - 249 WP_080806320.1 hypothetical protein -
XM38_RS05000 1083714..1083944 - 231 WP_080806322.1 transposase -
XM38_RS05005 1083916..1084926 - 1011 WP_088429252.1 pyridoxamine 5'-phosphate oxidase family protein -
XM38_RS05010 1084966..1085565 - 600 WP_080806324.1 glutathione S-transferase -
XM38_RS05015 1085713..1086261 + 549 WP_088429254.1 TetR/AcrR family transcriptional regulator -
XM38_RS05020 1086352..1087104 + 753 WP_080806328.1 aquaporin family protein -
XM38_RS05025 1087161..1087856 - 696 WP_088429256.1 glutathione S-transferase N-terminal domain-containing protein -
XM38_RS05030 1088031..1088378 - 348 WP_080806330.1 endoribonuclease MazF Toxin
XM38_RS05035 1088372..1088614 - 243 WP_080806331.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
XM38_RS05040 1088774..1088959 - 186 WP_088429258.1 hypothetical protein -
XM38_RS05045 1089108..1091225 - 2118 WP_080806335.1 tetratricopeptide repeat protein -
XM38_RS05050 1091790..1092188 - 399 WP_088429260.1 rhodanese-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(12-111)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13207.36 Da        Isoelectric Point: 6.7174

>T78057 WP_080806330.1 NZ_CP021983:c1088378-1088031 [Halomicronema hongdechloris C2206]
MVNPAERYIPDRGHILYLDFNPTKGHEQRGHRPAFVLSPRSYNAKSTLALFMPITRQQKGYPFEVLLPPELQIQGVILVD
QIKCLDWTARNVQFVEIVPDSLVEEVQAKIEPLIL

Download         Length: 348 bp

>T78057 NZ_CP021983:c1088378-1088031 [Halomicronema hongdechloris C2206]
TTGGTAAATCCGGCAGAGCGCTACATTCCTGATAGGGGCCACATCCTTTACCTAGACTTTAATCCAACTAAAGGTCATGA
ACAGCGAGGACACCGACCTGCGTTCGTACTGTCGCCTCGCAGTTACAACGCCAAAAGCACCCTGGCACTGTTTATGCCTA
TTACTAGGCAGCAAAAGGGGTATCCCTTTGAAGTTCTCTTACCGCCTGAACTACAGATTCAAGGGGTGATTCTTGTTGAT
CAGATCAAGTGTCTAGATTGGACAGCCCGTAACGTTCAGTTCGTTGAGATTGTTCCAGATAGCTTAGTTGAAGAGGTGCA
GGCAAAAATCGAACCCCTGATTTTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8787.09 Da        Isoelectric Point: 5.0509

>AT78057 WP_080806331.1 NZ_CP021983:c1088614-1088372 [Halomicronema hongdechloris C2206]
MVATVTKWGNSLALRIPQHIAKEIQLTEGAEVDLAVIDGNLVIKPRPRRRYSLEELIAAITPETLHSEVETGVAVGNEAW

Download         Length: 243 bp

>AT78057 NZ_CP021983:c1088614-1088372 [Halomicronema hongdechloris C2206]
ATGGTTGCGACAGTTACCAAGTGGGGCAATAGTTTGGCCCTTCGGATTCCCCAACACATCGCCAAAGAGATTCAGCTAAC
TGAAGGCGCTGAAGTTGATCTAGCGGTGATTGACGGTAATTTGGTAATCAAACCGAGACCTCGTAGGCGCTATTCTTTAG
AGGAGTTAATAGCGGCTATCACACCAGAGACTTTGCATTCTGAAGTGGAGACTGGAGTCGCTGTGGGGAATGAGGCTTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References