Detailed information of TA system TA078038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-KacA/DUF1778(antitoxin)
• Location: 2294962..2295756
• Replicon: chromosome
• Accession: NZ_CP021971
• Organism: Hafnia alvei strain CBA7135

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: CD201_RS10725
• Protein ID: WP_096387615.1
• Coordinates: 2295235..2295756 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: KacA
• Uniprot ID: A0A097R2F1
• Locus tag: CD201_RS10720
• Protein ID: WP_025801385.1
• Coordinates: 2294962..2295231 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD201_RS10705	2290560..2291591	-	1032	WP_043493238.1	Mal regulon transcriptional regulator MalI	-
CD201_RS10710	2291842..2293437	+	1596	WP_111329514.1	maltose/glucose-specific PTS transporter subunit IIBC	-
CD201_RS10715	2293521..2294696	+	1176	WP_025801384.1	pyridoxal phosphate-dependent aminotransferase	-
CD201_RS10720	2294962..2295231	+	270	WP_025801385.1	DUF1778 domain-containing protein	Antitoxin
CD201_RS10725	2295235..2295756	+	522	WP_096387615.1	GNAT family N-acetyltransferase	Toxin
CD201_RS10730	2295954..2296952	+	999	WP_103009725.1	adenosine deaminase	-
CD201_RS10735	2297550..2298545	-	996	WP_111329516.1	bile acid:sodium symporter	-
CD201_RS10740	2298707..2299750	-	1044	WP_111329518.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (92-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-88)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 19412.24 Da
• Isoelectric Point: 6.9676

>T78038 WP_096387615.1 NZ_CP021971:2295235-2295756 [Hafnia alvei]
MPDLTIAIFSSEAEYDFSDFDCGEESLNVFLTDHLARQHNARILRGYLLITQTLKPKVVGYYTLSGSCFEKETLPSNTQK
RKVPYVNVPSITLGRLAIQKDLHGQEWGTALVTHAMQVVYRASLAVGVHGMFVDALNEKAKQFYLKLGFIALTGNNANSL
FYPTKSIEKLFED

Nucleotide

• Length: 522 bp

>T78038 NZ_CP021971:2295235-2295756 [Hafnia alvei]
ATGCCTGACTTAACCATTGCGATTTTTTCGAGTGAGGCTGAATACGATTTCTCCGACTTTGACTGCGGCGAAGAATCCCT
GAATGTATTCCTTACCGATCATTTGGCCCGCCAGCATAATGCGCGAATTTTACGTGGCTATTTACTCATAACCCAAACGC
TAAAACCCAAAGTCGTTGGTTATTACACGCTATCTGGTAGCTGCTTCGAAAAGGAAACGCTGCCGTCAAATACCCAGAAA
CGCAAAGTGCCTTATGTCAACGTACCCAGTATCACTTTAGGGCGTCTCGCCATTCAAAAAGATCTCCATGGACAAGAATG
GGGAACGGCGCTGGTGACTCACGCGATGCAAGTGGTTTATCGAGCATCGCTTGCCGTGGGCGTTCACGGTATGTTTGTCG
ATGCACTCAATGAGAAAGCAAAGCAGTTCTACCTGAAGCTTGGATTTATCGCTCTCACGGGCAATAACGCAAACTCGCTT
TTCTACCCAACCAAATCCATCGAAAAGCTGTTCGAGGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10097.51 Da
• Isoelectric Point: 5.8580

>AT78038 WP_025801385.1 NZ_CP021971:2294962-2295231 [Hafnia alvei]
MSALKKQRIDLRLTDEDKNAIEEAAAMSNQTITQFMLTSASERAAEVIEQHRRLILSDESWNLVMDAISTPPAPNDRLKR
AAKRLQSME

Nucleotide

• Length: 270 bp

>AT78038 NZ_CP021971:2294962-2295231 [Hafnia alvei]
ATGTCTGCATTAAAAAAACAGCGTATCGATCTTCGCTTAACTGACGAAGACAAAAACGCCATTGAAGAAGCAGCGGCGAT
GTCCAACCAAACTATCACGCAGTTTATGCTTACCAGCGCCTCTGAACGTGCAGCGGAAGTTATCGAGCAACACCGTCGCT
TGATCCTCAGCGATGAGTCATGGAACCTGGTAATGGATGCCATCAGCACCCCACCGGCACCGAACGATAGACTTAAACGC
GCAGCCAAACGTCTGCAAAGTATGGAATAG

Structures

Antitoxin

• AlphaFold DB: A0A097R2F1