Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 562534..563170 Replicon chromosome
Accession NZ_CP021970
Organism Bacillus licheniformis strain CBA7132

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag CD200_RS02820 Protein ID WP_003179128.1
Coordinates 562820..563170 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag CD200_RS02815 Protein ID WP_006638778.1
Coordinates 562534..562815 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD200_RS02795 557649..559130 + 1482 WP_009330132.1 PH domain-containing protein -
CD200_RS02800 559127..559726 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
CD200_RS02805 560069..561028 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
CD200_RS02810 561253..562422 + 1170 WP_026080763.1 alanine racemase -
CD200_RS02815 562534..562815 + 282 WP_006638778.1 hypothetical protein Antitoxin
CD200_RS02820 562820..563170 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CD200_RS02825 563288..564115 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
CD200_RS02830 564119..564484 + 366 WP_003179132.1 STAS domain-containing protein -
CD200_RS02835 564487..564888 + 402 WP_003179135.1 anti-sigma regulatory factor -
CD200_RS02840 564899..565906 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
CD200_RS02845 565965..566291 + 327 WP_003179140.1 anti-sigma factor antagonist -
CD200_RS02850 566291..566776 + 486 WP_003179142.1 anti-sigma B factor RsbW -
CD200_RS02855 566742..567533 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
CD200_RS02860 567530..568129 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T78032 WP_003179128.1 NZ_CP021970:562820-563170 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T78032 NZ_CP021970:562820-563170 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT78032 WP_006638778.1 NZ_CP021970:562534-562815 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT78032 NZ_CP021970:562534-562815 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References