Detailed information of TA system TA078031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1261762..1262367
• Replicon: chromosome
• Accession: NZ_CP021965
• Organism: Paenibacillus odorifer strain CBA7130

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A1R0YSQ6
• Locus tag: CD191_RS05500
• Protein ID: WP_036686777.1
• Coordinates: 1262017..1262367 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: CD191_RS05495
• Protein ID: WP_154117276.1
• Coordinates: 1261762..1262013 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD191_RS05475	1257147..1258532	+	1386	WP_111502784.1	helix-turn-helix transcriptional regulator	-
CD191_RS05480	1258681..1258854	+	174	WP_111502786.1	aspartyl-phosphate phosphatase Spo0E family protein	-
CD191_RS05485	1259061..1260146	+	1086	WP_076137665.1	outer membrane lipoprotein carrier protein LolA	-
CD191_RS05490	1260335..1261516	+	1182	WP_076137663.1	alanine racemase	-
CD191_RS05495	1261762..1262013	+	252	WP_154117276.1	ribbon-helix-helix protein, CopG family	Antitoxin
CD191_RS05500	1262017..1262367	+	351	WP_036686777.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CD191_RS05505	1262576..1263133	+	558	WP_172628782.1	TetR family transcriptional regulator	-
CD191_RS05510	1263305..1264504	+	1200	WP_076137661.1	MFS transporter	-
CD191_RS05515	1264744..1266906	+	2163	WP_179088937.1	RNA-binding transcriptional accessory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-35)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12778.71 Da
• Isoelectric Point: 5.1284

>T78031 WP_036686777.1 NZ_CP021965:1262017-1262367 [Paenibacillus odorifer]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDESLQISLGLIDF

Nucleotide

• Length: 351 bp

>T78031 NZ_CP021965:1262017-1262367 [Paenibacillus odorifer]
TTGATCGTTAAACGTGGCGATGTTTTTTTTGCTGATCTTTCGCCGGTTGTAGGTTCTGAACAAGGCGGAGTAAGGCCAGT
TCTGGTCATCCAGAACGATATTGGCAATCGCTTTAGCCCGACGGTAATTGTGGCTGCAATCACAGCCCAAATCCAGAAGG
CTAAGTTACCTACACATGTGGAAATTGACGCAGCTGCTCATGGCTTTGACAGAGATTCTGTTATTTTGCTGGAACAGGTT
AGGACGATTGACAAACAACGCTTAACTGACAAGATCACCCACCTTGATGATGAAACGATGAAAAAGGTGGATGAATCGCT
GCAAATCAGCCTTGGTCTGATTGATTTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9487.94 Da
• Isoelectric Point: 5.1184

>AT78031 WP_154117276.1 NZ_CP021965:1261762-1262013 [Paenibacillus odorifer]
MISLPDHLLQEVDGIVQLENSNRSELIRQAMKLYLSERRKRSIRESMQRGYMEMAKINLTMACEAFLAEEDADSTLGRLV
SGV

Nucleotide

• Length: 252 bp

>AT78031 NZ_CP021965:1261762-1262013 [Paenibacillus odorifer]
ATGATCAGCTTGCCCGATCATCTCTTGCAGGAAGTGGACGGAATTGTTCAATTGGAGAATTCCAACCGGAGTGAATTGAT
TAGGCAGGCCATGAAGCTGTACTTGAGCGAACGGAGGAAACGTTCCATCCGGGAGTCCATGCAGCGCGGCTACATGGAAA
TGGCTAAGATCAACTTGACCATGGCATGCGAGGCTTTCCTCGCGGAGGAAGATGCAGACAGCACTCTTGGCCGCTTAGTA
AGCGGGGTGTAG

Structures

Toxin

• AlphaFold DB: A0A1R0YSQ6