Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4163856..4164382 Replicon chromosome
Accession NZ_CP021960
Organism Klebsiella pneumoniae strain AR_0139

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AM386_RS22570 Protein ID WP_000323025.1
Coordinates 4164095..4164382 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag AM386_RS22565 Protein ID WP_000534858.1
Coordinates 4163856..4164095 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM386_RS22540 4160184..4161422 + 1239 WP_003030308.1 IS110 family transposase -
AM386_RS22550 4161898..4162470 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
AM386_RS22555 4162670..4163593 + 924 WP_020277922.1 cation diffusion facilitator family transporter -
AM386_RS22565 4163856..4164095 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AM386_RS22570 4164095..4164382 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AM386_RS22575 4164449..4165483 - 1035 Protein_4053 IS481 family transposase -
AM386_RS22580 4165543..4165704 + 162 WP_032426744.1 type I toxin-antitoxin system Hok family toxin -
AM386_RS22585 4165865..4166350 - 486 WP_020277937.1 hypothetical protein -
AM386_RS22595 4166618..4167259 - 642 WP_000134999.1 MBL fold metallo-hydrolase -
AM386_RS22600 4167499..4168761 - 1263 WP_000608644.1 IS1380-like element ISEc9 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4160184..4168761 8577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T78020 WP_000323025.1 NZ_CP021960:4164095-4164382 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T78020 NZ_CP021960:4164095-4164382 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT78020 WP_000534858.1 NZ_CP021960:4163856-4164095 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT78020 NZ_CP021960:4163856-4164095 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References