Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2068363..2068994 | Replicon | chromosome |
Accession | NZ_CP021955 | ||
Organism | Klebsiella pneumoniae strain AR_0107 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A1Q8YTV3 |
Locus tag | AM486_RS10480 | Protein ID | WP_012542177.1 |
Coordinates | 2068363..2068539 (+) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A2X1QFN9 |
Locus tag | AM486_RS10485 | Protein ID | WP_012542176.1 |
Coordinates | 2068587..2068994 (+) | Length | 136 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM486_RS10460 | 2063751..2064782 | + | 1032 | WP_088296168.1 | DUF968 domain-containing protein | - |
AM486_RS10465 | 2064795..2065136 | + | 342 | WP_017898982.1 | antitermination protein Q | - |
AM486_RS10470 | 2065161..2066195 | - | 1035 | WP_088296426.1 | DNA cytosine methyltransferase | - |
AM486_RS10475 | 2066215..2067969 | - | 1755 | WP_163597061.1 | ATP-binding protein | - |
AM486_RS10480 | 2068363..2068539 | + | 177 | WP_012542177.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
AM486_RS10485 | 2068587..2068994 | + | 408 | WP_012542176.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
AM486_RS10490 | 2069709..2069978 | + | 270 | WP_032439907.1 | holin | - |
AM486_RS10495 | 2069956..2070453 | + | 498 | WP_088296428.1 | lysozyme | - |
AM486_RS10500 | 2070450..2070800 | + | 351 | WP_017898986.1 | hypothetical protein | - |
AM486_RS10515 | 2072178..2072399 | + | 222 | WP_032439852.1 | hypothetical protein | - |
AM486_RS10520 | 2072553..2072915 | + | 363 | WP_017898990.1 | HNH endonuclease | - |
AM486_RS10525 | 2072867..2073184 | + | 318 | WP_014228902.1 | hypothetical protein | - |
AM486_RS10530 | 2073181..2073612 | + | 432 | WP_077259664.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2045851..2102130 | 56279 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6632.83 Da Isoelectric Point: 11.0174
>T77992 WP_012542177.1 NZ_CP021955:2068363-2068539 [Klebsiella pneumoniae]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
Download Length: 177 bp
>T77992 NZ_CP021955:2068363-2068539 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14977.99 Da Isoelectric Point: 4.4277
>AT77992 WP_012542176.1 NZ_CP021955:2068587-2068994 [Klebsiella pneumoniae]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
Download Length: 408 bp
>AT77992 NZ_CP021955:2068587-2068994 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q8YTV3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2X1QFN9 |