Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5274119..5274776 Replicon chromosome
Accession NZ_CP021939
Organism Klebsiella pneumoniae strain AR_0145

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM392_RS26230 Protein ID WP_002916310.1
Coordinates 5274119..5274529 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM392_RS26235 Protein ID WP_002916312.1
Coordinates 5274510..5274776 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM392_RS26210 5270119..5271852 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
AM392_RS26215 5271858..5272571 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM392_RS26220 5272594..5273490 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM392_RS26225 5273591..5274112 + 522 WP_004144730.1 flavodoxin FldB -
AM392_RS26230 5274119..5274529 - 411 WP_002916310.1 protein YgfX Toxin
AM392_RS26235 5274510..5274776 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM392_RS26240 5275022..5276005 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AM392_RS26245 5276156..5276815 - 660 WP_002916317.1 hemolysin III family protein -
AM392_RS26250 5276979..5277290 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AM392_RS26255 5277340..5278068 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AM392_RS26260 5278187..5279620 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T77945 WP_002916310.1 NZ_CP021939:c5274529-5274119 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T77945 NZ_CP021939:c5274529-5274119 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT77945 WP_002916312.1 NZ_CP021939:c5274776-5274510 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT77945 NZ_CP021939:c5274776-5274510 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References