Detailed information of TA system TA077901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3025924..3026744
• Replicon: chromosome
• Accession: NZ_CP021935
• Organism: Escherichia coli strain AR_0055

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AM434_RS15455
• Protein ID: WP_001054379.1
• Coordinates: 3026487..3026744 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AM434_RS15450
• Protein ID: WP_000123957.1
• Coordinates: 3025924..3026475 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM434_RS15420	3021618..3022931	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AM434_RS15425	3022943..3023221	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AM434_RS15430	3023218..3024339	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AM434_RS29805	3024584..3024700	-	117	Protein_2815	VOC family protein	-
AM434_RS15440	3024738..3024998	-	261	WP_000077645.1	hypothetical protein	-
AM434_RS15445	3025126..3025872	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AM434_RS15450	3025924..3026475	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AM434_RS15455	3026487..3026744	-	258	WP_001054379.1	YjhX family toxin	Toxin
AM434_RS15465	3027121..3027285	-	165	Protein_2820	GNAT family N-acetyltransferase	-
AM434_RS15475	3028528..3029634	+	1107	Protein_2822	helicase YjhR	-
AM434_RS15485	3030217..3031197	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T77901 WP_001054379.1 NZ_CP021935:c3026744-3026487 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T77901 NZ_CP021935:c3026744-3026487 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT77901 WP_000123957.1 NZ_CP021935:c3026475-3025924 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT77901 NZ_CP021935:c3026475-3025924 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030