Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 260081..260912 Replicon chromosome
Accession NZ_CP021935
Organism Escherichia coli strain AR_0055

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag AM434_RS01490 Protein ID WP_000854815.1
Coordinates 260538..260912 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag AM434_RS01485 Protein ID WP_001280918.1
Coordinates 260081..260449 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM434_RS01435 255170..255916 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
AM434_RS01440 255999..256349 + 351 Protein_256 hypothetical protein -
AM434_RS01445 256365..256775 + 411 WP_000846703.1 hypothetical protein -
AM434_RS01455 256996..257814 + 819 WP_001542275.1 DUF945 domain-containing protein -
AM434_RS01460 257814..258059 + 246 WP_001164966.1 hypothetical protein -
AM434_RS01465 258153..258626 + 474 WP_001542276.1 antirestriction protein -
AM434_RS01470 258642..259118 + 477 WP_001186200.1 RadC family protein -
AM434_RS01475 259181..259402 + 222 WP_000692345.1 DUF987 domain-containing protein -
AM434_RS01480 259421..260065 + 645 WP_000086752.1 hypothetical protein -
AM434_RS01485 260081..260449 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM434_RS01490 260538..260912 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM434_RS01495 260909..261103 + 195 WP_000988600.1 hypothetical protein -
AM434_RS29300 261116..261229 + 114 WP_001161660.1 DUF957 domain-containing protein -
AM434_RS01500 261518..261664 - 147 Protein_268 transposase domain-containing protein -
AM434_RS01505 261718..261870 + 153 WP_050482493.1 ethanolamine utilization protein -
AM434_RS01510 261952..262377 + 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
AM434_RS01515 262374..262724 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
AM434_RS01520 262755..264368 + 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
AM434_RS01525 264541..264870 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T77888 WP_000854815.1 NZ_CP021935:260538-260912 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T77888 NZ_CP021935:260538-260912 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT77888 WP_001280918.1 NZ_CP021935:260081-260449 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT77888 NZ_CP021935:260081-260449 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References