Detailed information of TA system TA077879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4069..4739
• Replicon: plasmid pAP1468-3
• Accession: NZ_CP021925
• Organism: Acetobacter pasteurianus subsp. Pasteurianus strain SRCM101468

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C7JJA1
• Locus tag: S101468_RS16070
• Protein ID: WP_012813391.1
• Coordinates: 4069..4491 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: S101468_RS16075
• Protein ID: WP_041633476.1
• Coordinates: 4488..4739 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S101468_RS16040	1..300	+	300	WP_012813395.1	transcriptional regulator	-
S101468_RS16045	507..1034	+	528	WP_082179792.1	helix-turn-helix domain-containing protein	-
S101468_RS16050	1389..1862	+	474	WP_012813394.1	ParA family protein	-
S101468_RS16055	2017..2256	+	240	WP_012813393.1	recombinase family protein	-
S101468_RS16060	2314..3699	+	1386	WP_012812390.1	IS1380-like element IS1380A family transposase	-
S101468_RS16065	3842..4069	-	228	WP_012813392.1	hypothetical protein	-
S101468_RS16070	4069..4491	-	423	WP_012813391.1	type II toxin-antitoxin system VapC family toxin	Toxin
S101468_RS16075	4488..4739	-	252	WP_041633476.1	plasmid stabilization protein	Antitoxin
S101468_RS16080	4805..7890	-	3086	Protein_8	Ti-type conjugative transfer relaxase TraA	-
S101468_RS16085	7987..8346	+	360	WP_012813388.1	conjugal transfer protein TraD	-
S101468_RS16090	8411..8649	+	239	Protein_10	conjugal transfer protein TraD	-
S101468_RS16095	8753..9085	+	333	WP_012813386.1	hypothetical protein	-
S101468_RS16785	9088..9258	+	171	WP_162010041.1	hypothetical protein	-
S101468_RS16100	9354..9608	-	255	WP_012813384.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49900	49900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 20769.92 Da
• Isoelectric Point: 5.5500

>T77879 WP_012813391.1 NZ_CP021925:c4491-4069 [Acetobacter pasteurianus subsp. Pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 423 bp

>T77879 NZ_CP021925:c4491-4069 [Acetobacter pasteurianus subsp. Pasteurianus]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT77879 WP_041633476.1 NZ_CP021925:c4739-4488 [Acetobacter pasteurianus subsp. Pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT77879 NZ_CP021925:c4739-4488 [Acetobacter pasteurianus subsp. Pasteurianus]
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Structures

Toxin

• AlphaFold DB: C7JJA1