Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4183845..4184481 Replicon chromosome
Accession NZ_CP021920
Organism Bacillus sonorensis strain SRCM101395

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag S101395_RS22105 Protein ID WP_003179128.1
Coordinates 4183845..4184195 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag S101395_RS22110 Protein ID WP_006638778.1
Coordinates 4184200..4184481 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S101395_RS22065 4178887..4179486 - 600 WP_006638786.1 SpoIIE family protein phosphatase -
S101395_RS22070 4179483..4180274 - 792 WP_006638785.1 RNA polymerase sigma factor SigB -
S101395_RS22075 4180240..4180722 - 483 WP_006638784.1 anti-sigma B factor RsbW -
S101395_RS22080 4180722..4181048 - 327 WP_006638783.1 anti-sigma factor antagonist -
S101395_RS22085 4181107..4182114 - 1008 WP_006638782.1 PP2C family protein-serine/threonine phosphatase -
S101395_RS22090 4182125..4182526 - 402 WP_006638781.1 anti-sigma regulatory factor -
S101395_RS22095 4182529..4182894 - 366 WP_006638780.1 STAS domain-containing protein -
S101395_RS22100 4182898..4183725 - 828 WP_006638779.1 RsbT co-antagonist protein RsbRA -
S101395_RS22105 4183845..4184195 - 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
S101395_RS22110 4184200..4184481 - 282 WP_006638778.1 hypothetical protein Antitoxin
S101395_RS22115 4184586..4185761 - 1176 WP_006638777.1 alanine racemase -
S101395_RS22120 4185976..4186992 - 1017 WP_087962525.1 outer membrane lipoprotein carrier protein LolA -
S101395_RS22125 4187274..4187873 + 600 WP_006638775.1 rhomboid family intramembrane serine protease -
S101395_RS22130 4187870..4189351 - 1482 WP_040348458.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T77873 WP_003179128.1 NZ_CP021920:c4184195-4183845 [Bacillus sonorensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T77873 NZ_CP021920:c4184195-4183845 [Bacillus sonorensis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGATATGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATC
CGGACGATTGATAAGCAAAGATTAACGGACAAAATCACTCATCTCGATGATGAAATGATGGAAAAGGTCAATGAAGCCTT
ACAAATCAGTTTGGCACTTATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT77873 WP_006638778.1 NZ_CP021920:c4184481-4184200 [Bacillus sonorensis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT77873 NZ_CP021920:c4184481-4184200 [Bacillus sonorensis]
TTGTCTGAATCCAGCGCTACAACTGAAATTTTGATTCGCTTGCCAGAGGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGTGAACGCAAAAATCGACAAATTC
GAGAATCGATGAGACGCGGTTATATGGAGATGGCAAAGATCAATTTGAACATCTCTTCAGAGGCACAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References