Detailed information of TA system TA077872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 3296093..3297012
• Replicon: chromosome
• Accession: NZ_CP021920
• Organism: Bacillus sonorensis strain SRCM101395

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: M5PDF4
• Locus tag: S101395_RS17310
• Protein ID: WP_006638546.1
• Coordinates: 3296093..3296839 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: A0A7Y8RVI2
• Locus tag: S101395_RS17315
• Protein ID: WP_029418621.1
• Coordinates: 3296839..3297012 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S101395_RS17295	3292264..3294024	-	1761	WP_006638543.1	gamma-glutamyltransferase	-
S101395_RS17300	3294352..3294969	+	618	WP_006638544.1	DUF47 domain-containing protein	-
S101395_RS17305	3294982..3295980	+	999	WP_006638545.1	inorganic phosphate transporter	-
S101395_RS17310	3296093..3296839	+	747	WP_006638546.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
S101395_RS17315	3296839..3297012	+	174	WP_029418621.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
S101395_RS17320	3297312..3298580	-	1269	WP_006638548.1	MFS transporter	-
S101395_RS17325	3298608..3299624	-	1017	WP_006638549.1	zinc-binding alcohol dehydrogenase family protein	-
S101395_RS17330	3299644..3300492	-	849	WP_006638550.1	SDR family oxidoreductase	-
S101395_RS17335	3300468..3301565	-	1098	WP_006638551.1	mannonate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-57)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29647.11 Da
• Isoelectric Point: 4.6172

>T77872 WP_006638546.1 NZ_CP021920:3296093-3296839 [Bacillus sonorensis]
MLLFYQFSVWVIVLALALYVFAVWRFEKKMKEKTIAIRKTWYLLYVIGAVIYWTYNPQSLFTDPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSNELATDTRELLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGDIEAYAEGIEKLIKRFAEKMNISASL
CEYNSEQSKDHLLEHMENRFAVQEKLERKDVYYEENGKMVLIPFSIHEYDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PYEEEGDE

Nucleotide

• Length: 747 bp

>T77872 NZ_CP021920:3296093-3296839 [Bacillus sonorensis]
ATGCTGCTTTTTTATCAATTCTCAGTTTGGGTTATCGTTCTGGCTTTGGCTCTGTACGTTTTTGCCGTGTGGCGCTTTGA
AAAAAAGATGAAAGAAAAAACGATTGCCATCCGGAAAACCTGGTATCTCCTTTATGTAATCGGCGCCGTGATTTACTGGA
CGTACAATCCGCAGTCCCTTTTTACAGACCCGCTTCATTATCTGATCGTCGCCGTTTTTTTCACGCTGACCGATGCATTT
ATTTTCTTAAACGCCTACTTTAAAAAACTGGGCAGCAATGAACTGGCGACAGACACAAGAGAGCTGCTCGAAGAAAACAA
CGACCTGCTTCACACCTATCAAAACAGGCTGAAAACGTTCCAATACCTATTGAAAAACGAACCGATTCACATCTATTATG
GAGATATAGAAGCTTATGCAGAAGGCATTGAAAAACTCATTAAACGGTTTGCCGAAAAAATGAATATATCTGCCTCACTC
TGTGAATATAATTCAGAGCAGAGCAAAGATCATTTGCTTGAACACATGGAAAACCGTTTCGCTGTTCAGGAAAAGCTGGA
GCGAAAAGATGTATATTACGAAGAAAACGGAAAAATGGTCCTGATTCCATTTTCTATCCATGAATACGACTATGTCATGA
AACTGACTTCCGAGGACCTTGTCACTGAATTTGATTATCTTCTGTTTACTTCTTTAACGAGCATCTATGATCTCCTGCTA
CCATACGAAGAGGAAGGTGACGAATGA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6961.93 Da
• Isoelectric Point: 10.7390

>AT77872 WP_029418621.1 NZ_CP021920:3296839-3297012 [Bacillus sonorensis]
MEPVFQHDEDRSIKRGAWKVFKKQSRTNIAKYELSPHTERIFRQNARLIDEYKRKNA

Nucleotide

• Length: 174 bp

>AT77872 NZ_CP021920:3296839-3297012 [Bacillus sonorensis]
ATGGAGCCGGTTTTTCAGCACGACGAAGACCGTTCAATCAAGCGCGGCGCGTGGAAAGTATTTAAAAAACAATCGAGAAC
AAATATCGCCAAATATGAACTCAGCCCTCATACCGAACGGATTTTCAGACAAAATGCACGGCTGATTGATGAGTATAAAC
GAAAAAATGCCTGA

Structures

Toxin

• AlphaFold DB: M5PDF4

Antitoxin

• AlphaFold DB: A0A7Y8RVI2