Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 152768..154284 Replicon chromosome
Accession NZ_CP021912
Organism Erythrobacter sp. KY5

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CD351_RS00705 Protein ID WP_111990847.1
Coordinates 152768..154030 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CD351_RS00710 Protein ID WP_111993510.1
Coordinates 154027..154284 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD351_RS00695 148790..150274 - 1485 WP_111990845.1 type I restriction-modification system subunit M -
CD351_RS00700 150278..152653 - 2376 WP_111990846.1 DEAD/DEAH box helicase family protein -
CD351_RS00705 152768..154030 - 1263 WP_111990847.1 type II toxin-antitoxin system HipA family toxin Toxin
CD351_RS00710 154027..154284 - 258 WP_111993510.1 helix-turn-helix transcriptional regulator Antitoxin
CD351_RS00715 154584..155801 - 1218 WP_111993511.1 tyrosine-type recombinase/integrase -
CD351_RS00725 156252..157256 + 1005 WP_111990848.1 complex I NDUFA9 subunit family protein -
CD351_RS00730 157514..158404 - 891 WP_111990849.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-62)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45170.55 Da        Isoelectric Point: 5.3414

>T77871 WP_111990847.1 NZ_CP021912:c154030-152768 [Erythrobacter sp. KY5]
VTLPILDTLAVWWGERQAGELSIDKGGALHFAYSPDWLADEKVPALSQAMPKQEEPFGDHACKAVFGGLLPEESQRTAIA
RALGVSPDNPFRLLEALGGDVAGALAFLPQGEEPLQDYSKTAPEPLHEGGLAELLDRLPSVPMLAGEGGARLSLAGAQSK
LPVVLTTDGGIAIPRPGEPSTHLIKPEPDRFPGLAANEAFCLALARALGIDAAHAEWRTAAGKPFLLVERYDRISVEGTA
HRLHQEDFAQALGVPSNRKYAAEGGPTFRDSFALLRSAATRPAREVLKLADAAIFNLIIGNADAHAKNYSLLRLEAGEVV
LAPLYDLVATHMWKELSPKLAMRFGRAATLEEFDGENVVRFAEEAGLGAPYIRRRIGELAQSIVHENEKGVAVPGYIHKD
SIAKIAECTVERAKLAEYKL

Download         Length: 1263 bp

>T77871 NZ_CP021912:c154030-152768 [Erythrobacter sp. KY5]
GTGACGCTGCCGATCCTGGACACGCTGGCTGTATGGTGGGGCGAGCGTCAGGCAGGCGAACTCTCCATCGACAAAGGCGG
CGCGCTGCATTTCGCCTATTCGCCAGACTGGCTGGCTGACGAAAAGGTCCCGGCACTTTCCCAAGCAATGCCAAAGCAGG
AAGAGCCATTTGGCGATCATGCCTGCAAGGCTGTCTTTGGAGGTCTGCTGCCCGAAGAAAGCCAGCGCACGGCTATCGCT
CGGGCACTTGGGGTTTCGCCCGACAACCCATTTCGTCTGCTAGAGGCCTTGGGTGGAGATGTTGCCGGTGCTCTCGCATT
TTTGCCTCAGGGAGAAGAACCGCTCCAAGACTACTCCAAGACTGCTCCAGAACCACTCCATGAGGGCGGACTAGCGGAAC
TGCTCGATCGGTTGCCTTCCGTGCCCATGCTGGCAGGCGAGGGCGGCGCGAGGCTCAGCCTTGCAGGGGCTCAGAGCAAA
CTGCCCGTGGTGCTCACCACCGACGGAGGCATCGCGATCCCACGTCCGGGCGAGCCCTCCACACATCTGATCAAACCCGA
GCCGGATCGCTTTCCCGGTCTGGCCGCCAATGAAGCCTTCTGCCTCGCTTTGGCACGCGCCCTAGGCATTGATGCGGCCC
ATGCAGAGTGGCGCACCGCTGCGGGGAAGCCATTTCTGCTGGTCGAACGCTATGATCGGATCTCTGTTGAAGGAACAGCA
CACAGACTGCACCAGGAAGACTTCGCCCAGGCACTCGGCGTACCCTCGAACCGGAAATACGCTGCAGAGGGTGGCCCGAC
TTTCCGCGATAGCTTCGCGCTTCTACGCAGCGCGGCCACTCGCCCCGCGCGTGAAGTGCTAAAGCTAGCTGACGCTGCGA
TCTTCAATCTCATCATCGGCAATGCCGATGCACACGCTAAGAACTACAGCCTGCTAAGACTTGAGGCCGGCGAGGTGGTC
CTTGCACCGCTTTATGATCTTGTCGCTACGCACATGTGGAAGGAACTCTCCCCAAAGCTCGCAATGCGATTTGGCCGTGC
GGCAACCTTGGAGGAGTTCGACGGAGAGAATGTGGTGCGCTTCGCGGAGGAGGCGGGGCTGGGTGCGCCATACATCCGTC
GAAGGATTGGAGAGCTGGCACAGTCCATCGTTCACGAGAATGAAAAAGGGGTGGCAGTTCCGGGATATATTCACAAAGAC
AGCATAGCAAAGATCGCTGAATGTACAGTCGAGCGAGCGAAATTGGCAGAGTACAAGCTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9305.89 Da        Isoelectric Point: 5.1724

>AT77871 WP_111993510.1 NZ_CP021912:c154284-154027 [Erythrobacter sp. KY5]
MLDVATIGQIIRDERKELGLRQDELAAASGVGLRFLVELERGKPTVQMGKALDVLAALGCELRIKRPDGIVIAGQMDEFK
KDKAE

Download         Length: 258 bp

>AT77871 NZ_CP021912:c154284-154027 [Erythrobacter sp. KY5]
ATGCTCGATGTTGCCACTATCGGCCAGATCATTCGCGATGAACGCAAGGAGCTTGGACTACGCCAAGACGAACTGGCTGC
AGCAAGCGGAGTGGGCTTGCGCTTCCTTGTCGAGCTGGAGCGAGGAAAGCCCACCGTCCAGATGGGCAAGGCGCTCGATG
TGCTCGCCGCCCTTGGATGCGAACTGCGGATCAAGCGCCCCGACGGAATCGTCATCGCCGGTCAGATGGATGAGTTCAAG
AAGGACAAAGCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References