Detailed information of TA system TA077837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2050492..2051021
• Replicon: chromosome
• Accession: NZ_CP021905
• Organism: Staphylococcus aureus strain Seattle 1945 isolate G477

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0C6DV13
• Locus tag: CD017_RS10450
• Protein ID: WP_001103929.1
• Coordinates: 2050492..2050809 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CD017_RS10455
• Protein ID: WP_001058486.1
• Coordinates: 2050812..2051021 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD017_RS10415	2045802..2046143	-	342	WP_001161492.1	hypothetical protein	-
CD017_RS10420	2046490..2047131	-	642	WP_038413070.1	pathogenicity island protein	-
CD017_RS10425	2047128..2047412	-	285	WP_000998182.1	hypothetical protein	-
CD017_RS10430	2047414..2047776	-	363	WP_001039171.1	hypothetical protein	-
CD017_RS10440	2048073..2049542	-	1470	WP_001834090.1	virulence-associated E family protein	-
CD017_RS10445	2049559..2050428	-	870	WP_001002839.1	primase alpha helix C-terminal domain-containing protein	-
CD017_RS10450	2050492..2050809	-	318	WP_001103929.1	DUF1474 family protein	Toxin
CD017_RS10455	2050812..2051021	-	210	WP_001058486.1	hypothetical protein	Antitoxin
CD017_RS14555	2051014..2051160	-	147	WP_000833313.1	hypothetical protein	-
CD017_RS10460	2051157..2051474	-	318	WP_000481972.1	helix-turn-helix domain-containing protein	-
CD017_RS10465	2051488..2052129	-	642	WP_000595329.1	phage repressor protein	-
CD017_RS10470	2052133..2052345	-	213	WP_000448765.1	helix-turn-helix transcriptional regulator	-
CD017_RS10475	2052499..2053161	+	663	WP_001070979.1	helix-turn-helix transcriptional regulator	-
CD017_RS10480	2053174..2054346	+	1173	WP_000024832.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2038090..2056391	18301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12666.19 Da
• Isoelectric Point: 4.5462

>T77837 WP_001103929.1 NZ_CP021905:c2050809-2050492 [Staphylococcus aureus]
MNWEIKDLICDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HELEKASSENFDEESDDAQKLKITE

Nucleotide

• Length: 318 bp

>T77837 NZ_CP021905:c2050809-2050492 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATATGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAATTAGAAAAAGCATCATCTGAGAACTTTGACGAGGAATCAGATGACGCGCAGAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT77837 WP_001058486.1 NZ_CP021905:c2051021-2050812 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT77837 NZ_CP021905:c2051021-2050812 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A0C6DV13