Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 826342..826819 Replicon chromosome
Accession NZ_CP021905
Organism Staphylococcus aureus strain Seattle 1945 isolate G477

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CD017_RS04045 Protein ID WP_000052076.1
Coordinates 826342..826530 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CD017_RS04050 Protein ID WP_001059690.1
Coordinates 826559..826819 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD017_RS04015 822295..822852 + 558 WP_000824491.1 hypothetical protein -
CD017_RS04020 823193..823879 + 687 WP_001574556.1 thermonuclease family protein -
CD017_RS04025 824236..824436 + 201 WP_001059082.1 cold-shock protein -
CD017_RS04030 824933..825151 - 219 WP_000005879.1 hypothetical protein -
CD017_RS04035 825213..825497 - 285 WP_001004401.1 hypothetical protein -
CD017_RS04040 825585..826154 - 570 WP_001106663.1 hypothetical protein -
CD017_RS04045 826342..826530 - 189 WP_000052076.1 hypothetical protein Toxin
CD017_RS04050 826559..826819 - 261 WP_001059690.1 hypothetical protein Antitoxin
CD017_RS04055 827161..827364 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CD017_RS04060 827361..827597 - 237 WP_000368687.1 hypothetical protein -
CD017_RS04065 827822..828403 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CD017_RS04070 828476..829093 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
CD017_RS04075 829249..829743 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CD017_RS04080 830142..830564 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CD017_RS04085 830712..831428 + 717 WP_000150022.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T77832 WP_000052076.1 NZ_CP021905:c826530-826342 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T77832 NZ_CP021905:c826530-826342 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT77832 WP_001059690.1 NZ_CP021905:c826819-826559 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT77832 NZ_CP021905:c826819-826559 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References