Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3700302..3701014 Replicon chromosome
Accession NZ_CP021904
Organism Alkalitalea saponilacus strain SC/BZ-SP2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CDL62_RS14025 Protein ID WP_198314176.1
Coordinates 3700302..3700499 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CDL62_RS14030 Protein ID WP_079557249.1
Coordinates 3700649..3701014 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDL62_RS14005 3695740..3698544 + 2805 WP_079557251.1 hypothetical protein -
CDL62_RS14010 3698529..3699515 + 987 WP_079557250.1 hypothetical protein -
CDL62_RS14025 3700302..3700499 + 198 WP_198314176.1 type II toxin-antitoxin system HicA family toxin Toxin
CDL62_RS14030 3700649..3701014 + 366 WP_079557249.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CDL62_RS14035 3701118..3701336 + 219 WP_079557248.1 addiction module protein -
CDL62_RS14040 3701336..3701629 + 294 WP_079557247.1 type II toxin-antitoxin system RelE/ParE family toxin -
CDL62_RS18580 3701888..3702055 + 168 WP_157666520.1 hypothetical protein -
CDL62_RS14045 3702155..3702418 + 264 WP_079557246.1 hypothetical protein -
CDL62_RS14050 3702960..3703892 + 933 WP_079557245.1 DUF3137 domain-containing protein -
CDL62_RS14055 3704215..3705117 - 903 WP_143255043.1 hypothetical protein -
CDL62_RS14060 3705234..3705953 - 720 WP_088328664.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7627.05 Da        Isoelectric Point: 10.5393

>T77830 WP_198314176.1 NZ_CP021904:3700302-3700499 [Alkalitalea saponilacus]
MSKREKLIARFLTMPSDFHYDEMVKLLGYFEFREVRKGKTSGSRVKFMNPDGLPIMLHKPTHLGL

Download         Length: 198 bp

>T77830 NZ_CP021904:3700302-3700499 [Alkalitalea saponilacus]
ATGTCTAAAAGAGAAAAGTTAATAGCCCGTTTTTTGACTATGCCATCTGATTTTCATTACGATGAGATGGTTAAGCTTTT
AGGCTATTTTGAATTTAGAGAAGTGAGAAAAGGGAAAACTTCGGGTTCCCGGGTTAAGTTTATGAATCCAGATGGATTGC
CCATAATGCTTCATAAGCCGACCCATCTGGGATTATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13568.41 Da        Isoelectric Point: 6.4771

>AT77830 WP_079557249.1 NZ_CP021904:3700649-3701014 [Alkalitalea saponilacus]
MKNLEHKGYTGSIEYSKEDDLLYGKVLGINGLISYEGKTGSELEADFKAAVDAYLSDCKEEGITPEKPFKGSFNVRISAE
LHQKAALLAMEDRMSLNNFVAESIRERVFRIFGKLSPRTSR

Download         Length: 366 bp

>AT77830 NZ_CP021904:3700649-3701014 [Alkalitalea saponilacus]
ATGAAAAATTTAGAACATAAAGGATATACAGGAAGCATTGAATACAGCAAAGAAGATGATTTGTTGTATGGAAAAGTTCT
TGGTATCAATGGTCTGATATCTTATGAAGGGAAAACAGGCAGTGAGTTAGAAGCTGATTTTAAAGCAGCTGTTGATGCAT
ATTTGTCTGACTGTAAGGAAGAGGGGATTACACCAGAAAAGCCCTTTAAAGGCAGTTTTAATGTTCGGATTTCGGCCGAG
CTTCATCAGAAAGCAGCTTTACTTGCAATGGAGGATAGAATGTCATTAAATAACTTTGTTGCAGAATCTATTAGAGAAAG
AGTTTTTCGGATATTTGGAAAATTATCCCCCCGCACAAGTCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References