77823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4369645..4370265 Replicon chromosome
Accession NZ_CP021902
Organism Enterobacter cloacae complex sp. strain AR_0136

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag AM383_RS22375 Protein ID WP_015571250.1
Coordinates 4369645..4369863 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag AM383_RS22380 Protein ID WP_006809850.1
Coordinates 4369891..4370265 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM383_RS22345 (AM383_22225) 4365657..4365917 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
AM383_RS22350 (AM383_22230) 4365920..4366060 + 141 WP_032608666.1 type B 50S ribosomal protein L36 -
AM383_RS22355 (AM383_22235) 4366057..4366767 - 711 WP_022650493.1 GNAT family protein -
AM383_RS22360 (AM383_22240) 4366869..4368329 + 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
AM383_RS22365 (AM383_22245) 4368301..4368768 - 468 WP_022650495.1 YlaC family protein -
AM383_RS22370 (AM383_22250) 4368885..4369436 - 552 WP_022650496.1 maltose O-acetyltransferase -
AM383_RS22375 (AM383_22255) 4369645..4369863 - 219 WP_015571250.1 HHA domain-containing protein Toxin
AM383_RS22380 (AM383_22260) 4369891..4370265 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
AM383_RS22385 (AM383_22265) 4370776..4373922 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
AM383_RS22390 (AM383_22270) 4373945..4375138 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T77823 WP_015571250.1 NZ_CP021902:c4369863-4369645 [Enterobacter cloacae complex sp.]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T77823 NZ_CP021902:c4369863-4369645 [Enterobacter cloacae complex sp.]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT77823 WP_006809850.1 NZ_CP021902:c4370265-4369891 [Enterobacter cloacae complex sp.]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT77823 NZ_CP021902:c4370265-4369891 [Enterobacter cloacae complex sp.]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGCCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References