Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2183024..2183681 Replicon chromosome
Accession NZ_CP021902
Organism Enterobacter cloacae complex sp. strain AR_0136

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag AM383_RS11590 Protein ID WP_022649305.1
Coordinates 2183024..2183434 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM383_RS11595 Protein ID WP_003863437.1
Coordinates 2183415..2183681 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM383_RS11570 (AM383_11480) 2179022..2180755 - 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -
AM383_RS11575 (AM383_11485) 2180761..2181474 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM383_RS11580 (AM383_11490) 2181503..2182399 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM383_RS11585 (AM383_11495) 2182501..2183022 + 522 WP_003863440.1 flavodoxin FldB -
AM383_RS11590 (AM383_11500) 2183024..2183434 - 411 WP_022649305.1 protein YgfX Toxin
AM383_RS11595 (AM383_11505) 2183415..2183681 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM383_RS11600 (AM383_11510) 2183976..2184956 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
AM383_RS11605 (AM383_11515) 2185042..2185701 - 660 WP_003863433.1 hemolysin III family protein -
AM383_RS11610 (AM383_11520) 2185968..2186699 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
AM383_RS11615 (AM383_11525) 2186816..2187739 + 924 Protein_2108 6-phospho-beta-glucosidase -
AM383_RS11620 (AM383_11530) 2187803..2188507 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2187803..2188507 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T77819 WP_022649305.1 NZ_CP021902:c2183434-2183024 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T77819 NZ_CP021902:c2183434-2183024 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT77819 WP_003863437.1 NZ_CP021902:c2183681-2183415 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT77819 NZ_CP021902:c2183681-2183415 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References