77806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4615009..4615666 Replicon chromosome
Accession NZ_CP021896
Organism Enterobacter cloacae complex sp. strain AR_0050

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag AM429_RS22365 Protein ID WP_022649305.1
Coordinates 4615009..4615419 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM429_RS22370 Protein ID WP_003863437.1
Coordinates 4615400..4615666 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM429_RS22345 (AM429_22245) 4611007..4612740 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
AM429_RS22350 (AM429_22250) 4612746..4613459 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM429_RS22355 (AM429_22255) 4613488..4614384 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM429_RS22360 (AM429_22260) 4614486..4615007 + 522 WP_015571793.1 flavodoxin FldB -
AM429_RS22365 (AM429_22265) 4615009..4615419 - 411 WP_022649305.1 protein YgfX Toxin
AM429_RS22370 (AM429_22270) 4615400..4615666 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM429_RS22375 (AM429_22275) 4615961..4616941 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
AM429_RS22385 (AM429_22285) 4617465..4618124 - 660 WP_022649307.1 hemolysin III family protein -
AM429_RS22390 (AM429_22290) 4618391..4619122 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T77806 WP_022649305.1 NZ_CP021896:c4615419-4615009 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T77806 NZ_CP021896:c4615419-4615009 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT77806 WP_003863437.1 NZ_CP021896:c4615666-4615400 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT77806 NZ_CP021896:c4615666-4615400 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References