77805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4334285..4335024 Replicon chromosome
Accession NZ_CP021896
Organism Enterobacter cloacae complex sp. strain AR_0050

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag AM429_RS21005 Protein ID WP_022649088.1
Coordinates 4334644..4335024 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag AM429_RS21000 Protein ID WP_022649087.1
Coordinates 4334285..4334611 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM429_RS20985 (AM429_20885) 4330179..4332839 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
AM429_RS20990 (AM429_20890) 4333469..4333792 + 324 WP_022649085.1 antirestriction protein -
AM429_RS20995 (AM429_20895) 4333807..4334274 + 468 WP_022649086.1 DNA repair protein RadC -
AM429_RS21000 (AM429_20900) 4334285..4334611 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM429_RS21005 (AM429_20905) 4334644..4335024 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
AM429_RS21010 (AM429_20910) 4335021..4335248 + 228 WP_022649089.1 DUF5983 family protein -
AM429_RS21015 (AM429_20915) 4335640..4335933 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
AM429_RS21020 (AM429_20920) 4336277..4337593 - 1317 WP_022649091.1 amidase family protein -
AM429_RS21025 (AM429_20925) 4337648..4338943 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4311176..4335933 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T77805 WP_022649088.1 NZ_CP021896:4334644-4335024 [Enterobacter cloacae complex sp.]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T77805 NZ_CP021896:4334644-4335024 [Enterobacter cloacae complex sp.]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT77805 WP_022649087.1 NZ_CP021896:4334285-4334611 [Enterobacter cloacae complex sp.]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT77805 NZ_CP021896:4334285-4334611 [Enterobacter cloacae complex sp.]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References