Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1298089..1298618 Replicon chromosome
Accession NZ_CP021885
Organism Enterococcus faecium strain WEFA23

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag CDW54_RS06635 Protein ID WP_002294198.1
Coordinates 1298352..1298618 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag CDW54_RS06630 Protein ID WP_002294199.1
Coordinates 1298089..1298352 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDW54_RS06615 1295464..1297287 + 1824 WP_002294202.1 APC family permease -
CDW54_RS06620 1297429..1297614 - 186 WP_002294201.1 hypothetical protein -
CDW54_RS06630 1298089..1298352 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CDW54_RS06635 1298352..1298618 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
CDW54_RS06640 1298819..1299307 + 489 WP_002328046.1 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase -
CDW54_RS12735 1299370..1299537 + 168 WP_002294195.1 hypothetical protein -
CDW54_RS06645 1299849..1300520 - 672 WP_002319469.1 ABC transporter permease -
CDW54_RS06650 1300517..1301434 - 918 WP_002328047.1 osmoprotectant ABC transporter substrate-binding protein -
CDW54_RS06655 1301431..1302072 - 642 WP_002293405.1 ABC transporter permease -
CDW54_RS06660 1302076..1303251 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T77787 WP_002294198.1 NZ_CP021885:1298352-1298618 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T77787 NZ_CP021885:1298352-1298618 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT77787 WP_002294199.1 NZ_CP021885:1298089-1298352 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT77787 NZ_CP021885:1298089-1298352 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References