Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3735151..3735789 Replicon chromosome
Accession NZ_CP021879
Organism Escherichia coli strain AR_0137

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag AM384_RS19065 Protein ID WP_001447010.1
Coordinates 3735613..3735789 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM384_RS19060 Protein ID WP_001270286.1
Coordinates 3735151..3735567 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM384_RS19040 3730303..3731244 - 942 WP_001251304.1 ABC transporter permease -
AM384_RS19045 3731245..3732258 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
AM384_RS19050 3732276..3733421 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
AM384_RS19055 3733666..3735072 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
AM384_RS19060 3735151..3735567 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
AM384_RS19065 3735613..3735789 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
AM384_RS19070 3736011..3736241 + 231 WP_000494244.1 YncJ family protein -
AM384_RS19075 3736333..3738294 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
AM384_RS19080 3738367..3738903 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
AM384_RS19085 3738956..3740170 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T77772 WP_001447010.1 NZ_CP021879:c3735789-3735613 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T77772 NZ_CP021879:c3735789-3735613 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT77772 WP_001270286.1 NZ_CP021879:c3735567-3735151 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT77772 NZ_CP021879:c3735567-3735151 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References