Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3182964..3183799 Replicon chromosome
Accession NZ_CP021879
Organism Escherichia coli strain AR_0137

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7I6H0K3
Locus tag AM384_RS16090 Protein ID WP_000854760.1
Coordinates 3182964..3183341 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag AM384_RS16095 Protein ID WP_001295723.1
Coordinates 3183431..3183799 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM384_RS16060 3178484..3178957 + 474 WP_001105416.1 DNA gyrase inhibitor SbmC -
AM384_RS16065 3179155..3180213 + 1059 WP_001200890.1 FUSC family protein -
AM384_RS16070 3180385..3180714 + 330 WP_000450409.1 DUF496 family protein -
AM384_RS16075 3180815..3180997 - 183 WP_001016348.1 hypothetical protein -
AM384_RS26730 3181028..3181180 - 153 Protein_2942 propanediol utilization protein -
AM384_RS27085 3181451..3181822 - 372 WP_001295631.1 IS110 family transposase -
AM384_RS26735 3182638..3182751 - 114 WP_032140621.1 DUF957 domain-containing protein -
AM384_RS16085 3182764..3182967 - 204 WP_000761705.1 hypothetical protein -
AM384_RS16090 3182964..3183341 - 378 WP_000854760.1 TA system toxin CbtA family protein Toxin
AM384_RS16095 3183431..3183799 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM384_RS16105 3183962..3184183 - 222 WP_000692345.1 DUF987 domain-containing protein -
AM384_RS16110 3184252..3184728 - 477 WP_001354275.1 RadC family protein -
AM384_RS26740 3184744..3185217 - 474 WP_001387789.1 antirestriction protein -
AM384_RS16120 3185559..3186377 - 819 WP_047149353.1 DUF945 domain-containing protein -
AM384_RS16130 3186496..3187193 - 698 Protein_2952 IS1 family transposase -
AM384_RS16140 3187249..3187881 + 633 Protein_2953 IS30-like element IS30 family transposase -
AM384_RS16145 3187891..3188139 - 249 Protein_2954 transposase -
AM384_RS26745 3188570..3188734 + 165 WP_001128468.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14165.19 Da        Isoelectric Point: 7.3249

>T77762 WP_000854760.1 NZ_CP021879:c3183341-3182964 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T77762 NZ_CP021879:c3183341-3182964 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT77762 WP_001295723.1 NZ_CP021879:c3183799-3183431 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT77762 NZ_CP021879:c3183799-3183431 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H0K3

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References