Detailed information of TA system TA077734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 220226..220838
• Replicon: chromosome
• Accession: NZ_CP021870
• Organism: Streptococcus agalactiae strain SG-M4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: BB165_RS01325
• Protein ID: WP_000384859.1
• Coordinates: 220226..220561 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: BB165_RS01330
• Protein ID: WP_000259017.1
• Coordinates: 220551..220838 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB165_RS01295	215424..216065	+	642	WP_000591144.1	hypothetical protein	-
BB165_RS01305	216365..217240	+	876	WP_000421240.1	hypothetical protein	-
BB165_RS01310	217276..217710	+	435	WP_001220479.1	hypothetical protein	-
BB165_RS01315	218027..219283	+	1257	WP_000122836.1	plasmid recombination protein	-
BB165_RS01320	219451..219921	+	471	WP_000130119.1	hypothetical protein	-
BB165_RS01325	220226..220561	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BB165_RS01330	220551..220838	-	288	WP_000259017.1	hypothetical protein	Antitoxin
BB165_RS01335	221346..221636	+	291	WP_000078282.1	WXG100 family type VII secretion target	-
BB165_RS01340	221738..222145	+	408	WP_000749962.1	hypothetical protein	-
BB165_RS01345	222231..222638	+	408	WP_000749955.1	hypothetical protein	-
BB165_RS01350	222638..223225	+	588	WP_011074703.1	hypothetical protein	-
BB165_RS01355	223607..223849	+	243	WP_001134681.1	hypothetical protein	-
BB165_RS01360	223834..224220	+	387	WP_088203008.1	hypothetical protein	-
BB165_RS01365	224254..224535	+	282	WP_000052404.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T77734 WP_000384859.1 NZ_CP021870:c220561-220226 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T77734 NZ_CP021870:c220561-220226 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT77734 WP_000259017.1 NZ_CP021870:c220838-220551 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT77734 NZ_CP021870:c220838-220551 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6