Detailed information of TA system TA077733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2092254..2092878
• Replicon: chromosome
• Accession: NZ_CP021868
• Organism: Streptococcus agalactiae strain SG-M8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: BB159_RS10775
• Protein ID: WP_000253103.1
• Coordinates: 2092254..2092601 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: BB159_RS10780
• Protein ID: WP_000543070.1
• Coordinates: 2092591..2092878 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB159_RS10755	2087969..2088325	-	357	WP_000105935.1	DUF1304 domain-containing protein	-
BB159_RS10760	2088392..2090710	-	2319	WP_000883417.1	YhgE/Pip domain-containing protein	-
BB159_RS10765	2090849..2091388	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
BB159_RS10770	2091474..2091770	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
BB159_RS10775	2092254..2092601	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BB159_RS10780	2092591..2092878	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BB159_RS10785	2092947..2093324	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
BB159_RS11360	2093299..2093451	-	153	Protein_2009	DUF1492 domain-containing protein	-
BB159_RS10790	2093458..2093946	-	489	WP_000891152.1	hypothetical protein	-
BB159_RS10795	2094019..2094576	-	558	WP_001258764.1	hypothetical protein	-
BB159_RS10800	2094734..2094907	-	174	WP_000694573.1	hypothetical protein	-
BB159_RS10805	2094904..2095161	-	258	WP_001069293.1	hypothetical protein	-
BB159_RS10810	2095454..2096848	-	1395	WP_000656430.1	hypothetical protein	-
BB159_RS10815	2096860..2097717	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2091474..2106050	14576

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T77733 WP_000253103.1 NZ_CP021868:c2092601-2092254 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T77733 NZ_CP021868:c2092601-2092254 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT77733 WP_000543070.1 NZ_CP021868:c2092878-2092591 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT77733 NZ_CP021868:c2092878-2092591 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5