77729

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 701089..701632 Replicon chromosome
Accession NZ_CP021867
Organism Streptococcus agalactiae strain SG-M25

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag BB164_RS04095 Protein ID WP_002943355.1
Coordinates 701363..701632 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag BB164_RS04090 Protein ID WP_002326825.1
Coordinates 701089..701361 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB164_RS04050 696676..696915 + 240 WP_000635249.1 peptide-binding protein -
BB164_RS04055 696964..697047 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
BB164_RS04060 697172..697909 + 738 WP_088196767.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
BB164_RS04070 698079..698339 + 261 Protein_704 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
BB164_RS04075 698411..699756 + 1346 WP_166724132.1 IS3 family transposase -
BB164_RS04080 699868..700764 + 897 WP_002326827.1 ParA family protein -
BB164_RS04085 700862..701071 + 210 WP_000527318.1 peptide-binding protein -
BB164_RS04090 701089..701361 + 273 WP_002326825.1 antitoxin Antitoxin
BB164_RS04095 701363..701632 + 270 WP_002943355.1 zeta toxin family protein Toxin
BB164_RS04105 701730..702051 + 322 Protein_710 DUF4368 domain-containing protein -
BB164_RS04110 702044..703003 + 960 Protein_711 hypothetical protein -
BB164_RS04115 703074..703373 + 300 WP_050197324.1 hypothetical protein -
BB164_RS04120 703387..703677 + 291 WP_050197323.1 hypothetical protein -
BB164_RS04125 703773..704411 + 639 WP_050197322.1 hypothetical protein -
BB164_RS04130 704451..705551 + 1101 WP_050197321.1 toprim domain-containing protein -
BB164_RS04135 705579..705806 + 228 WP_000110922.1 hypothetical protein -
BB164_RS04140 705803..706192 + 390 WP_000048066.1 hypothetical protein -
BB164_RS04145 706243..706533 + 291 WP_000667951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) gbs0628 / gbs0630 636436..793170 156734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T77729 WP_002943355.1 NZ_CP021867:701363-701632 [Streptococcus agalactiae]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T77729 NZ_CP021867:701363-701632 [Streptococcus agalactiae]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAGAAGCACGTTCGCCAAT
GTCAACAAGAGAAATAACTTTAACAGTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT77729 WP_002326825.1 NZ_CP021867:701089-701361 [Streptococcus agalactiae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT77729 NZ_CP021867:701089-701361 [Streptococcus agalactiae]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References