Detailed information of TA system TA077727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 261020..261632
• Replicon: chromosome
• Accession: NZ_CP021867
• Organism: Streptococcus agalactiae strain SG-M25

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: BB164_RS01625
• Protein ID: WP_000384859.1
• Coordinates: 261020..261355 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: BB164_RS01630
• Protein ID: WP_000259017.1
• Coordinates: 261345..261632 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB164_RS01590	256172..256499	+	328	Protein_254	replication initiator protein A	-
BB164_RS01595	256503..257144	+	642	WP_000591145.1	hypothetical protein	-
BB164_RS01605	257444..258319	+	876	WP_000421237.1	hypothetical protein	-
BB164_RS01610	258355..258798	+	444	WP_001220481.1	hypothetical protein	-
BB164_RS01615	258821..260077	+	1257	WP_000122836.1	plasmid recombination protein	-
BB164_RS01620	260245..260715	+	471	WP_000130119.1	hypothetical protein	-
BB164_RS01625	261020..261355	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BB164_RS01630	261345..261632	-	288	WP_000259017.1	hypothetical protein	Antitoxin
BB164_RS01635	262139..262429	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
BB164_RS01640	262531..262938	+	408	WP_000749954.1	hypothetical protein	-
BB164_RS01645	262938..263498	+	561	WP_001865562.1	hypothetical protein	-
BB164_RS01650	263471..264151	+	681	WP_001865565.1	hypothetical protein	-
BB164_RS01655	264136..264522	+	387	WP_000259069.1	hypothetical protein	-
BB164_RS01660	264556..264837	+	282	WP_000052406.1	hypothetical protein	-
BB164_RS01680	265680..266540	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T77727 WP_000384859.1 NZ_CP021867:c261355-261020 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T77727 NZ_CP021867:c261355-261020 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT77727 WP_000259017.1 NZ_CP021867:c261632-261345 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT77727 NZ_CP021867:c261632-261345 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6