Detailed information of TA system TA077726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 265782..266394
• Replicon: chromosome
• Accession: NZ_CP021866
• Organism: Streptococcus agalactiae strain SG-M29

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: BB268_RS01645
• Protein ID: WP_000384860.1
• Coordinates: 265782..266117 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: BB268_RS01650
• Protein ID: WP_000259017.1
• Coordinates: 266107..266394 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB268_RS01615	260981..261622	+	642	WP_000591144.1	hypothetical protein	-
BB268_RS01625	261922..262767	+	846	WP_088187508.1	replication initiation protein	-
BB268_RS01630	262832..263266	+	435	WP_001220479.1	hypothetical protein	-
BB268_RS01635	263583..264839	+	1257	WP_000122836.1	plasmid recombination protein	-
BB268_RS01640	265007..265477	+	471	WP_000130119.1	hypothetical protein	-
BB268_RS01645	265782..266117	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BB268_RS01650	266107..266394	-	288	WP_000259017.1	hypothetical protein	Antitoxin
BB268_RS01655	266901..267191	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
BB268_RS01660	267293..267661	+	369	WP_001882138.1	hypothetical protein	-
BB268_RS01665	267699..268259	+	561	WP_001865562.1	hypothetical protein	-
BB268_RS01670	268232..268912	+	681	WP_001865565.1	hypothetical protein	-
BB268_RS01675	268897..269283	+	387	WP_000259069.1	hypothetical protein	-
BB268_RS01680	269317..269598	+	282	WP_017647916.1	hypothetical protein	-
BB268_RS01700	270441..271301	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T77726 WP_000384860.1 NZ_CP021866:c266117-265782 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T77726 NZ_CP021866:c266117-265782 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT77726 WP_000259017.1 NZ_CP021866:c266394-266107 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT77726 NZ_CP021866:c266394-266107 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6