Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3657430..3657946 Replicon chromosome
Accession NZ_CP021859
Organism Klebsiella pneumoniae strain AR_0125

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AM372_RS20375 Protein ID WP_002886902.1
Coordinates 3657662..3657946 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM372_RS20370 Protein ID WP_002886901.1
Coordinates 3657430..3657672 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM372_RS20355 3653459..3654199 + 741 WP_002886899.1 KDGP aldolase family protein -
AM372_RS20360 3654265..3655419 + 1155 WP_002886900.1 lactonase family protein -
AM372_RS20365 3655442..3657352 + 1911 WP_004152270.1 BglG family transcription antiterminator -
AM372_RS20370 3657430..3657672 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM372_RS20375 3657662..3657946 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM372_RS20380 3657950..3658414 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM372_RS20385 3658655..3660793 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AM372_RS20390 3661150..3661893 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM372_RS29960 3661896..3662069 - 174 WP_002886906.1 hypothetical protein -
AM372_RS20395 3662154..3662462 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T77712 WP_002886902.1 NZ_CP021859:3657662-3657946 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T77712 NZ_CP021859:3657662-3657946 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT77712 WP_002886901.1 NZ_CP021859:3657430-3657672 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT77712 NZ_CP021859:3657430-3657672 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References