Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 12741..13276 Replicon plasmid unitig_3
Accession NZ_CP021855
Organism Proteus mirabilis strain AR_0156

Toxin (Protein)


Gene name relE Uniprot ID A0A218N496
Locus tag AM403_RS21115 Protein ID WP_036896464.1
Coordinates 12741..13028 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A218N4B4
Locus tag AM403_RS21120 Protein ID WP_036896461.1
Coordinates 13025..13276 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM403_RS21075 7983..8498 + 516 WP_036896414.1 J domain-containing protein -
AM403_RS21080 8539..9105 + 567 WP_088207279.1 hypothetical protein -
AM403_RS21345 9108..9266 + 159 WP_153274249.1 hypothetical protein -
AM403_RS21085 9279..9509 + 231 WP_036896410.1 hypothetical protein -
AM403_RS21090 9502..9699 + 198 WP_049195515.1 helix-turn-helix domain-containing protein -
AM403_RS21095 9794..10126 + 333 WP_036896473.1 hypothetical protein -
AM403_RS21105 10930..11478 + 549 WP_036896470.1 hypothetical protein -
AM403_RS21110 11487..12650 + 1164 WP_036896467.1 relaxase/mobilization nuclease domain-containing protein -
AM403_RS21115 12741..13028 - 288 WP_036896464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM403_RS21120 13025..13276 - 252 WP_036896461.1 antitoxin Antitoxin
AM403_RS21125 13681..14091 + 411 WP_036896458.1 replication/maintenance protein RepL -
AM403_RS21130 14346..14615 + 270 WP_036896456.1 hypothetical protein -
AM403_RS21135 14766..15173 + 408 WP_012368878.1 cag pathogenicity island Cag12 family protein -
AM403_RS21140 15163..15711 + 549 WP_012368879.1 conjugal transfer protein -
AM403_RS21145 15925..16437 + 513 WP_012368881.1 hypothetical protein -
AM403_RS21150 16587..16781 + 195 WP_012368883.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23946 23946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11135.24 Da        Isoelectric Point: 10.6493

>T77693 WP_036896464.1 NZ_CP021855:c13028-12741 [Proteus mirabilis]
MMYSVKFRKDAEKEWKKLDKTIQSQFAKQLIKRCENPHVASAKLRNMPNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
REKSQVYNLASERLK

Download         Length: 288 bp

>T77693 NZ_CP021855:c13028-12741 [Proteus mirabilis]
ATGATGTATTCGGTTAAATTTAGAAAAGATGCAGAAAAGGAATGGAAAAAATTAGATAAAACCATTCAATCTCAATTTGC
CAAACAATTAATAAAACGATGTGAAAATCCACATGTAGCATCTGCAAAACTGAGAAATATGCCGAATTGCTATAAAATTA
AACTTCGTGCATCAGGTTTTAGATTGGTCTATCAAGTTATTGACGATATGTTAATTATTGCAGTTGTTGCCGTTGGCAAG
CGGGAAAAAAGTCAGGTTTATAATCTTGCCAGTGAACGCTTAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.45 Da        Isoelectric Point: 4.0548

>AT77693 WP_036896461.1 NZ_CP021855:c13276-13025 [Proteus mirabilis]
MPNTILSDTTASVSELKKNPMATVNAGLGYPVAILNRNQPAFYCVPAELYEQILDALDDNELAKLVKERESQPLVDINLA
EYL

Download         Length: 252 bp

>AT77693 NZ_CP021855:c13276-13025 [Proteus mirabilis]
ATGCCAAATACGATTTTAAGTGATACAACAGCCAGCGTCAGTGAACTCAAAAAAAACCCAATGGCGACAGTTAACGCAGG
TTTAGGCTATCCCGTAGCCATTTTAAACCGTAATCAACCTGCTTTTTACTGTGTTCCTGCTGAGTTATATGAGCAAATAC
TTGATGCGCTAGACGATAACGAACTTGCAAAGCTGGTCAAAGAACGAGAATCACAACCTCTTGTCGATATTAATTTAGCC
GAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A218N496

Antitoxin

Source ID Structure
AlphaFold DB A0A218N4B4

References