Detailed information of TA system TA077690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 2586955..2587654
• Replicon: chromosome
• Accession: NZ_CP021852
• Organism: Proteus mirabilis strain AR_0156

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: AM403_RS12195
• Protein ID: WP_004249093.1
• Coordinates: 2587268..2587654 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AM403_RS12190
• Protein ID: WP_004246828.1
• Coordinates: 2586955..2587275 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM403_RS12160	2582082..2582357	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
AM403_RS12165	2582412..2583035	-	624	WP_004246821.1	guanylate kinase	-
AM403_RS12170	2583337..2583954	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AM403_RS12175	2584091..2585377	+	1287	WP_017827115.1	DUF3748 domain-containing protein	-
AM403_RS12180	2585594..2586478	+	885	WP_004249091.1	endonuclease/exonuclease/phosphatase family protein	-
AM403_RS12185	2586471..2586905	+	435	WP_004246827.1	hypothetical protein	-
AM403_RS12190	2586955..2587275	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AM403_RS12195	2587268..2587654	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM403_RS12200	2587822..2589894	-	2073	WP_017827114.1	glycine--tRNA ligase subunit beta	-
AM403_RS12205	2589904..2590809	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AM403_RS12210	2591060..2591641	+	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T77690 WP_004249093.1 NZ_CP021852:c2587654-2587268 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T77690 NZ_CP021852:c2587654-2587268 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT77690 WP_004246828.1 NZ_CP021852:c2587275-2586955 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT77690 NZ_CP021852:c2587275-2586955 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97