Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4190200..4190857 Replicon chromosome
Accession NZ_CP021851
Organism Enterobacter cloacae strain A1137

Toxin (Protein)


Gene name cptA Uniprot ID A0A0F1AZ23
Locus tag CCL06_RS20455 Protein ID WP_025757758.1
Coordinates 4190200..4190610 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F1AVN1
Locus tag CCL06_RS20460 Protein ID WP_025757757.1
Coordinates 4190591..4190857 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCL06_RS20435 4186193..4187926 - 1734 WP_025757764.1 single-stranded-DNA-specific exonuclease RecJ -
CCL06_RS20440 4187932..4188645 - 714 WP_025757763.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCL06_RS20445 4188674..4189570 - 897 WP_025757762.1 site-specific tyrosine recombinase XerD -
CCL06_RS20450 4189672..4190193 + 522 WP_025757760.1 flavodoxin FldB -
CCL06_RS20455 4190200..4190610 - 411 WP_025757758.1 protein YgfX Toxin
CCL06_RS20460 4190591..4190857 - 267 WP_025757757.1 FAD assembly factor SdhE Antitoxin
CCL06_RS20465 4191152..4192132 + 981 WP_025757755.1 tRNA-modifying protein YgfZ -
CCL06_RS20470 4192217..4192876 - 660 WP_025757753.1 hemolysin III family protein -
CCL06_RS20475 4193142..4193873 + 732 WP_025757752.1 MurR/RpiR family transcriptional regulator -
CCL06_RS20480 4193990..4195423 + 1434 WP_025757751.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16047.99 Da        Isoelectric Point: 11.1910

>T77686 WP_025757758.1 NZ_CP021851:c4190610-4190200 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGT
EWDILGMPWMLNTGMMLRLRKVEGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T77686 NZ_CP021851:c4190610-4190200 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGCTGCTGATGCCATGGCCGCTGAGCTACACGCCGCTGTGGCTGCTGCTACTGTCGTTTGTTGTATTTGACAGCG
TACGCAGTCAGCGTCGCATCAATGCCCGTCAGGGAGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAACA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAATACCGGCATGATGTTACGGTTACGCAAGGTAGAAGGCGGACGTTG
CCAGCATCTGTGGCTGGCCGCTGACAGTATGGATGCGGCCGAGTGGCGAGACCTGCGCCGTATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.00 Da        Isoelectric Point: 5.1296

>AT77686 WP_025757757.1 NZ_CP021851:c4190857-4190591 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKHLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT77686 NZ_CP021851:c4190857-4190591 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATCCACTGGGCGTGTCGTCGCGGCATGCGTGAGCTTGATATTTCCATCATGCCTTT
CTTTGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCATCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1AZ23

Antitoxin

Source ID Structure
AlphaFold DB A0A0F1AVN1

References